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Giant
editGiant cell tumors, aneurysmal bone cysts, and Brown tumors/osteoclastomas are not the same thing. Giant cell tumors arise from the monocyte/macrophage system and have telomeric associations (end to end fusion chromosomes). These occur in skeletally mature young adults. Aneurysmal bone cysts are similar, but they are more of a reactive bone formation that happen to have giant cells. These occur primarily in adolescents. Osteoclastomas, while similar in appearance, are all alltogether different in terms of pathogenesis. These lesions are the complication of long standing hyperparathyroidism. Increased levels of parathyroid hormone stimulate osteoclasts to degrade bone in order to increase serum Calcium levels.
I am aware that these two tumors are not the same thing, but they are often together when a patient is diagnosed. Please leave me some feedback on my talk page and we can get this article cleaned up.
Bearingbreaker92 | Talk 12:13, 20 December 2006 (UTC)
In your section describing radiographic findings there is an erroneous description of GCT's being located in the epiphysis, when in fact, they usually start in the metaphysis and spread to the epiphyseal region. This epiphyseal spread is helpful in differentiating GCTs from other bubbly metaphyseal tumours. —Preceding unsigned comment added by 209.183.26.166 (talk) 12:40, 5 April 2011 (UTC)
Image
editIs this image applicable here?
-- CFCF (talk) 11:48, 7 November 2013 (UTC)