Talk:Elexacaftor/tezacaftor/ivacaftor

Wiki Education Foundation-supported course assignment

This article was the subject of a Wiki Education Foundation-supported course assignment, between 7 September 2021 and 13 December 2021. Further details are available on the course page. Student editor(s): Biomedjill.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 20:36, 17 January 2022 (UTC)

Merge proposal

Moving the stub, Elexacaftor, to here seems very reasonable. Best to consolidate closely-related material in one place. Klbrain (talk) 15:40, 10 February 2021 (UTC)

I find it awkward to have two or more drugboxes in one article. Also, I think it would be irritating to discuss one of the three components together with the combination, while the other two have their own articles. --ἀνυπόδητος (talk) 13:38, 18 February 2021 (UTC)

Fair enough; let's leave as-is; closing. Klbrain (talk) 07:23, 27 July 2021 (UTC)

Bibliography for updates

• Middleton, Peter G.; Mall, Marcus A.; Dřevínek, Pavel; Lands, Larry C.; McKone, Edward F.; Polineni, Deepika; Ramsey, Bonnie W.; Taylor-Cousar, Jennifer L.; Tullis, Elizabeth; Vermeulen, François; Marigowda, Gautham (2019-11-07). "Elexacaftor–Tezacaftor–Ivacaftor for Cystic Fibrosis with a Single Phe508del Allele". New England Journal of Medicine. 381 (19): 1809–1819. doi:10.1056/NEJMoa1908639. ISSN 0028-4793. PMC 7282384. PMID 31697873.
• Middleton PG, Mall MA, Dřevínek P, et al. Elexacaftor–tezacaftor–ivacaftor for cystic fibrosis with a single Phe508del allele. N Engl J Med. 2019;381(19):1809-1819. doi:10.1056/NEJMoa1908639
• Zemanick ET, Taylor-Cousar JL, Davies J, et al. A phase 3 open-label study of ELX/TEZ/IVA in children 6 through 11 years of age with CF and at least one F508del allele. Am J Respir Crit Care Med. 2021;203(12):1522-1532. doi: 10.1164/rccm.202102-0509OC
• Zaher A, Elsaygh J, Elsori D, et al. (July 03, 2021) A Review of Trikafta: Triple Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Modulator Therapy. Cureus 13(7): e16144. doi:10.7759/cureus.16144
• PhD, Ines Martins. "Trikafta Very Effective CF Therapy, But Still Too Costly, ICER Reports". Retrieved August 21, 2020.
• "Modulator Treatments for Cystic Fibrosis: Effectiveness and Value" (PDF). Institute for Clinical and Economic Review. Institute for Clinical and Economic Review. April 27, 2020. Retrieved August 21, 2020.
• Bethesda, Cystic Fibrosis Foundation 4550 Montgomery Ave Suite 1100 N.; Md 20814301-951-4422 800-344-4823. "FDA Approves Expansion of Modulators for People With Certain Rare Mutations". www.cff.org. Retrieved 2021-10-03.
• Bethesda, Cystic Fibrosis Foundation 4550 Montgomery Ave Suite 1100 N.; Md 20814301-951-4422 800-344-4823. "FDA Accepts Vertex Application for Expansion of Trikafta to Include Children ages 6-11". www.cff.org. Retrieved 2021-10-03.
• "Drugs@FDA: FDA-Approved Drugs". www.accessdata.fda.gov. Retrieved 2021-10-17.
• Vertex Pharmaceuticals. Trikafta (Elexacaftor/tezacaftor/ivacaftor) [package insert]. U.S. Food and Drug Administration website.https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/212273s004lbl.pdf. Revised June 2021. Accessed October 3, 2021.
• Vertex Pharmaceuticals. Trikafta (Elexacaftor/tezacaftor/ivacaftor) [clinical brochure] https://www.trikaftahcp.com/sites/default/files/clinical-brochure.pdf
• "Trikafta Side Effects". Drugs.com. January 24, 2021. Retrieved October 3, 2021.
• "elexacaftor/tezacaftor/ivacaftor (Rx)". Medscape. Retrieved October 3, 2021. — Preceding unsigned comment added by Biomedjill (talk • contribs) 18:56, 17 October 2021 (UTC)

Biomedjill (talk) 19:13, 17 October 2021 (UTC)

text formatting issue

In the table at https://en.wiki.x.io/wiki/Elexacaftor/tezacaftor/ivacaftor#Research there is a formatting issue (CSS? font-family? text-align?) in the cell on row "trial 3" and column "Target mutations", which is more obvious if you try to print the article onto paper — or save it as PDF. 2001:6B0:E:2B18:0:0:0:72 (talk) 17:31, 19 November 2022 (UTC)

NY Times article on the unavailability of Trikafta globally

Article here: [1]. Thriley (talk) 05:53, 8 February 2023 (UTC)

Mental side effects

Study here: [2]. Thriley (talk) 03:05, 13 February 2023 (UTC)

Weight gain and hypertension

Study here [3] ~dom Kaos~ (talk) 13:19, 12 June 2023 (UTC)

Merge figures

Would it make sense to merge the three figures for each of the components? I've seen other articles regarding combination drugs doing this. I wouldn't know how to do it myself. 82.147.226.240 (talk) 13:35, 6 October 2023 (UTC)