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Development of malaria resistance

Latest comment: 4 years ago1 comment1 person in discussion

These were misinterpreted but didn't end up being relevant so I'm putting them here with short summaries lest history repeat itself.

Administering Artemesia annua as dried whole leaves, "not a tea, not an infusion", may cause resistance to develop more slowly than if it is administered as pure artemisinin. (Also, "WHO has cautioned against use of nonpharmaceutical sources of artemisinin because of the risk of delivering subtherapeutic doses that could exacerbate the resistance problem. This warning is valid given the low artemisinin content of juice extractions, teas, and infusion preparations of plant material used for most nonpharmaceutical plant-based therapies.")^[1] Dried leaf Artemesia may also be helpful in cases where the malaria has become resistant to artemisinin combination therapy and artesunate.^[2]

Iamnotabunny (talk) 13:10, 11 June 2020 (UTC)Reply

References

^ Elfawal, Mostafa A.; Towler, Melissa J.; Reich, Nicholas G.; Weathers, Pamela J.; Rich, Stephen M. (20 January 2015). "Dried whole-plant Artemisia annua slows evolution of malaria drug resistance and overcomes resistance to artemisinin". Proceedings of the National Academy of Sciences United States of America. 112, 3. doi:10.1073/pnas.1413127112. Retrieved 5 June 2020.
^ Daddy, Nsengyumva Bati; Kalisya, Luc Malemo; Bagire, Pascal Gisenya; Watt, Robert L.; Towler, Melissa J.; Weathers, Pamela J. (15 August 2017). "Artemisia annua dried leaf tablets treated malaria resistant to ACT and i.v. artesunate: case reports". Phytomedicine: international journal of phytotherapy and phytopharmacology. 32 (2017). doi:10.1016/j.phymed.2017.04.006.

Add topic

[Elfawal2015-1] Elfawal, Mostafa A.; Towler, Melissa J.; Reich, Nicholas G.; Weathers, Pamela J.; Rich, Stephen M. (20 January 2015). "Dried whole-plant Artemisia annua slows evolution of malaria drug resistance and overcomes resistance to artemisinin". Proceedings of the National Academy of Sciences United States of America. 112, 3. doi:10.1073/pnas.1413127112. Retrieved 5 June 2020.

[2] Daddy, Nsengyumva Bati; Kalisya, Luc Malemo; Bagire, Pascal Gisenya; Watt, Robert L.; Towler, Melissa J.; Weathers, Pamela J. (15 August 2017). "Artemisia annua dried leaf tablets treated malaria resistant to ACT and i.v. artesunate: case reports". Phytomedicine: international journal of phytotherapy and phytopharmacology. 32 (2017). doi:10.1016/j.phymed.2017.04.006.

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