Talk:Carcinoid
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editI guess that this page should be fusionated with Carcinod Syndrome
Markers
editThis page is a bit of a stump. Can someone competent expand on it? Maybe a section about tumour markers and diagnostic? Mortality and impact on life quality? --Jan
There's 3 subjects which need merging/coordinating: carcinoid, carcinoid syndrome and neuroendocrine tumor. At the very least there should be easy links between the 3 Danielbirns (talk) 23:35, 5 February 2011 (UTC)
carcinoid syndrome
editLarry Kvols MD of Moffitt Cancer Center and Research Institute in Tampa, in "Carcinoid Tumors and the Carcinoid Syndrome: What's New in the Therapeutic Pipeline", presented at the Carcinoid Cancer Foundation's Carcinoid Symposium 2002, stresses flushing, diarrhea, CHF, and asthma as the four critical characteristics of carcinoid syndrome.
I suspect that the writer of this section may be mistaking the 5-10% incidence of carcinoid syndrome among carcinoid patients with a 5-10% incidence of secretion. I don't think that's true. Rather, the majority of carcinoids occur in regions drained by the mesenteric vasculature, leading to metabolism of serotonin to 5-HIAA in the liver before it reaches systemic circulation, preventing the evolution of carcinoid syndrome.
My suspicion is that far more than 10% of carcinoids secrete serotonin. — Preceding unsigned comment added by 155.41.112.1 (talk) 14:45, 1 December 2012 (UTC)
Markers
editThere's a list of markers, and a discussion of diagnosis, at neuroendocrine tumor.
please check Neuroendocrine Tumor article
editSee the neuroendocrine tumors discussion page for statistical citations.
I invite all interested parties to edit or criticize neuroendocrine tumors. Citations are on its discussion page.
Most common site of incidence of carcinoids is not the appendix!
editAs per the PAN-SEER data, the most common site for carcinoids is the foregut; bronchial carcinoids constituting the most common ones! Midgut is second in line with ileum constituting the second most prevalent site. And hindgut with rectum alone constitutes 13.6% cases. The appendix constitutes only 4.8% of all cases!
I have made the necessary corrections for this is evident in even the latest textbooks of medicine! —Preceding unsigned comment added by 122.162.87.106 (talk) 23:08, 6 September 2007 (UTC)
Serotonin Synthesis of Carcinoid
editSerotonin is synthesized from the amino acid tryptophan. Tryptophan is also used to synthesize niacin. In carcinoid, a larger percentage of the tryptophan is converted to serotonin. This can lead to a niacin deficiency leading to the development of pellagrous symptoms. —Preceding unsigned comment added by 152.33.56.0 (talk) 02:12, 28 February 2008 (UTC)
Carcinoid
editMy corrections would be. Interferon is sometimes helpful, not a regular treatment 2015. The article states 6% incidence of Carcinoid Syndrome. This happens usually when the cancer has spread to the liver or elsewhere, usually. Think the incidence is much higher than 6% All Carcinoids "have malignant potential", I think it is correct to say all carcinoids are malignant. 74.92.16.141 (talk) 04:07, 27 July 2015 (UTC) 74.92.16.141 (talk) 04:10, 27 July 2015 (UTC)
1 out of 5 males?
editCauses reads: "Carcinoid syndrome involves multiple tumors in one out of five males." Please clarify - for the sake of us female patients:) DyslexicDeficit (talk) 10:08, 5 January 2022 (UTC)