Talk:Acetylcarnitine

Untitled

I don't quite understand the following phrase. Could it be clarified, or corrected? "The L-carnitine is cycled back into the mitochondria by transporting more acyl groups..." Briancady413 (talk) 19:16, 20 January 2010 (UTC)

Citations

If proper citations are not provided within a week, i'll remove all of that text. -- Boris 15:53, 11 June 2006 (UTC)

Done. The citations I found that were not from dubious manufacturers' pages indicated that whatever benefits might be had, apart from end-stage renal disease and PAD, were inconclusive at best. I've made some changes to the text and added some sources, so as to not have the edit reverted as vandalism when it is indeed just removing unsupported claims. Zuiram 11:11, 1 October 2006 (UTC)

Thanks for ref-ifying my edit. Does the statement that many manufacturers claim life extension benefits really need sourcing? A simple google query returns many hits that posit this claim. Said claim is noted in the text to have no supporting evidence, and the text merely points out that such a claim is being made. Zuiram 00:25, 2 October 2006 (UTC)

Learn how to research.

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It is VERY troubling to me that the following has no citations:

"There is no effective way to significantly increase carnitine levels in humans via oral supplementation, as orally administered carnitine is rapidly excreted from the body, and the homeostasis mechanisms prevent significant cellular absorption.[citation needed] Further, over-the-counter supplements have been shown to contain less carnitine than advertised, and have further been shown to have poor absorption characteristics.[citation needed]"

WHY is it SO troubling??? Well, those are bold statements, especially in light of the fact that I did a Google search and saw a TON of published papers in medical journals where ORALLY administered forms of L-Carnitine and Acetyl L-Carnitine were reported to have statistically significant effects (double-blind studies). If citations cannot be provided to support the above claims within a few weeks, I am going to edit this article and provide citations of my own that contradict at least *part* of the above claims.

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"The percentage of L-carnitine that is absorbed when taken via oral supplementation is much lower than that from food sources. In one particular study, it was shown that approximately 20% of orally supplemented L-carnitine is absorbed, with a bioavailability of roughly 15%, as compared to a bioavailability of between 60% and 75% when absorbed from food.[4]"

L-carnitine and Acetyl-L-Carnitine are chemically different substances. The bioavailability of Acetyl-l-Carnitine is therefore different. This statement should not be in this article. —Preceding unsigned comment added by 67.132.205.2 (talk) 16:33, 4 June 2008 (UTC)

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I see there's no mention about a positive effect of Acetyl-L-Carnitine on various muscle diseases as well as heart conditions. I think this is an important health claim, too. Healthycare (talk) 11:58, 4 January 2010 (UTC)

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Easily the most important study of ALCAR is missing. Here's the link: Dietary Supplements Make Old Rats Youthful, May Rejuvenate Aging Humans (University of California) Here's scientific text: http://www.pnas.org/content/99/4/1876.full —Preceding unsigned comment added by 192.100.112.202 (talk) 12:13, 11 August 2010 (UTC)

"Valproate and Acetyl-l-carnitine Prevent Methamphetamine-Induced Behavioral Sensitization in Mice"

http://onlinelibrary.wiley.com/doi/10.1196/annals.1403.019/full ... Nagelfar (talk) 23:49, 14 February 2012 (UTC)

Health claims same as Carnitine?

The "Health claims" section seems to be just a poor copy of Carnitine#Potential_uses_as_a_pharmaceutical.

Does Acetylcarnitine actually have any benefits that are specific to it (i.e. you get them from Acetylcarnitine but not from L-carnitine)?

If not then this article should just say that the health benefits are the same as carnitine, instead of having a poor copy. Gronky (talk) 03:28, 4 January 2013 (UTC)

Report of new research, April 7, 2013

I am not qualified to properly evaluate the applicability of the info from the following link to this article. Here's the link: Forbe's article linking carnitine to artherosclerosis Can someone please have a look? Thank you, Peatbog (talk) 22:31, 7 April 2013 (UTC)

Peyronie's disease

I have removed the content below from the article space:

ALCAR has been shown to be more effective than tamoxifen in improving the curvature and reducing the pain and plaque sizes for men who sought treatment for their Peyronie's disease early and having low curvature deformities.

References

Discussion

• The face the editor has left their Google Books search text ("Carnitine improves libido") in the text does not give confidence. More generally, is this reliably sourced? Alexbrn ^{talk|contribs|COI} 07:20, 31 March 2014 (UTC)

Link to - and possible treatment of? - depression

Can someone link to this new study please?

• Acetyl-l-carnitine deficiency in patients with major depressive disorder
• Study links depression to low blood levels of acetyl-L-carnitine

And a new systematic review and meta-analysis:

• Acetyl-L-Carnitine Supplementation and the Treatment of Depressive Symptoms: A Systematic Review and Meta-Analysis.

Possible copyright problem

This article has been revised as part of a large-scale clean-up project of multiple article copyright infringement. (See the investigation subpage) Earlier text must not be restored, unless it can be verified to be free of infringement. For legal reasons, Wikipedia cannot accept copyrighted text or images borrowed from other web sites or printed material; such additions must be deleted. Contributors may use sources as a source of information, but not as a source of sentences or phrases. Accordingly, the material may be rewritten, but only if it does not infringe on the copyright of the original or plagiarize from that source. Please see our guideline on non-free text for how to properly implement limited quotations of copyrighted text. Wikipedia takes copyright violations very seriously. Moneytrees🌴^{Talk🌲Help out at CCI!} 21:44, 29 April 2020 (UTC)

2018 meta-analysis on depression

• Acetyl-L-Carnitine Supplementation and the Treatment of Depressive Symptoms: A Systematic Review and Meta-Analysis (2018) - is this a good-quality meta-analysis worthy of inclusion into the article, or is it low-quality? ---CopperKettle 13:47, 23 May 2020 (UTC)

Acyl vs Acetyl

I find the alternating use of Acyl and Acetyl confusing. While Acyl may be correct in modern usage, it is non-IUPAC, unfamiliar to me (a graduate chemist), and appears to be a typo to one not accustomed to the term. The article title is Acetylcarnitine, the compound is given in the header as 'Acetyl-L-carnitine'—why not stay with 'acetyl' for simplicity and clarity's sake? Add your comments, agree or disagree....

It gets worse: there's a dictionary out there, apparently authoritative, THE AMERICAN HERITAGE® SCIENCE DICTIONARY, cited in dictionary.com no less, which defines "acyl" as "...containing the group RCO, where R is a halogen." [emphasis mine]. That's not a definition of "acyl", that's an acyl halide, a completely different animal. That could really confuse someone who happened to look up the term there! I maintain that the use of "acyl" in the article is confusing to the lay reader & should be replaced. It is a 19th century German coinage, of limited English use; if you want to get technical, say "alkanoyl" or "alkyl carbonyl" with some mention of what the alkyl group can be. I am reluctant to do the edit myself as I am unclear as to how general "acyl" is intended to be here: is it just acetyl without the —OH, or are there other —RC=O groups implied, and if so, what Rs? I wouldn't touch this without a bunch of literature research, so I hope the original editor stops by, or someone familiar with the biochemistry of this class of compound. --D Anthony Patriarche (talk) 21:00, 5 May 2022 (UTC)