Talk:11-Deoxycortisol

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Alleged low blood pressure in 21-hydroxylase deficiency

Latest comment: 1 year ago2 comments1 person in discussion

@Christian75:@Medgirl131:@Wimvandorst:@Wimvandorst:@Edgar181:@Maneesh:

On 29 May 2009‎ an unauthenticated user from the IP address 146.203.126.113 added a brief note on clinical relevance of 11-deoxycortisol https://en.wiki.x.io/w/index.php?title=11-Deoxycortisol&oldid=292986319

The disputed addition is (quote): "In 11-beta-hydroxylase deficiency, 11-deoxycortisol levels increase dramatically, causing hypertension (as opposed to 21-alpha-hydroxylase deficiency, in which patients have hypotension from a lack of mineralocorticoids)."

There were no reference to support these claims.

In fact, in 11-beta-hydroxylase deficiency, it is 11-deoxycorticosterone that leads to hypertension, although it raises together with 11-deoxycortisol, but 11-deoxycortisol itself does not lead to hypertension. I have corrected this and added a reference.

However, I cannot find the explicit reference for the second part of the addition "(as opposed to 21-alpha-hydroxylase deficiency, in which patients have hypotension from a lack of mineralocorticoids)". I could not find an article that clearly states that hypotension is a symptom in 21-alpha-hydroxylase deficiency. There were some mentions pressure in some websites (that do not list sources) about low blood pressure in most severe salt-losing forms, but these symptoms are no longer found in most recent articles, reviews and practical guidelines about 21-hydroxylase deficiency.

---Maxim Masiutin (talk) 13:37, 28 September 2020 (UTC)Reply

I found references (PMID 9809193 and 36807213) to support the claim that in 11-beta-hydroxylase deficiency, 11-deoxycortisol levels increase dramatically, causing hypertension (as opposed to 21-alpha-hydroxylase deficiency, in which patients have hypotension from a lack of mineralocorticoids). Maxim Masiutin (talk) 10:00, 26 October 2023 (UTC)Reply

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