TP-003

TP-003
Identifiers
	IUPAC name 5-fluoro-2-[4-fluoro-3-[8-fluoro-7-(2-hydroxypropan-2-yl)imidazo[1,2-a]pyridin-3-yl]phenyl]benzonitrile;
CAS Number	628690-75-5 ;
PubChem CID	9978724;
ChemSpider	8154316 ;
CompTox Dashboard (EPA)	DTXSID101108234 ;
Chemical and physical data
Formula	C23H16F3N3O
Molar mass	407.396 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES N#Cc4cc(F)ccc4-c1cc(ccc1F)-c2cnc3n2ccc(C(C)(O)C)c3F;
	InChI InChI=1S/C23H16F3N3O/c1-23(2,30)18-7-8-29-20(12-28-22(29)21(18)26)17-10-13(3-6-19(17)25)16-5-4-15(24)9-14(16)11-27/h3-10,12,30H,1-2H3 ; Key:VLFITPUZJCLTFQ-UHFFFAOYSA-N ;
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TP-003 is an anxiolytic drug with a novel chemical structure, which is used in scientific research. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic. It is a positive allosteric modulator at the benzodiazepine binding site of GABA_A receptors.^[1] It has modest anticonvulsant activity although less than that of diazepam.^[2]

References

^ Neumann E, Ralvenius WT, Acuña MA, Rudolph U, Zeilhofer HU (2018). "TP003 is a non-selective benzodiazepine site agonist that induces anxiolysis via α2GABAA receptors". Neuropharmacology. 143: 71–78. doi:10.1016/j.neuropharm.2018.09.026. PMID 30240781. S2CID 52313196.
^ Fradley RL, Guscott MR, Bull S, Hallett DJ, Goodacre SC, Wafford KA, Garrett EM, Newman RJ, O'Meara GF, Whiting PJ, Rosahl TW, Dawson GR, Reynolds DS, Atack JR (Jun 2007). "Differential contribution of GABA(A) receptor subtypes to the anticonvulsant efficacy of benzodiazepine site ligands". Journal of Psychopharmacology. 21 (4): 384–91. doi:10.1177/0269881106067255. PMID 17092983. S2CID 34355306.

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[pmid30240781-1] Neumann E, Ralvenius WT, Acuña MA, Rudolph U, Zeilhofer HU (2018). "TP003 is a non-selective benzodiazepine site agonist that induces anxiolysis via α2GABAA receptors". Neuropharmacology. 143: 71–78. doi:10.1016/j.neuropharm.2018.09.026. PMID 30240781. S2CID 52313196.

[2] Fradley RL, Guscott MR, Bull S, Hallett DJ, Goodacre SC, Wafford KA, Garrett EM, Newman RJ, O'Meara GF, Whiting PJ, Rosahl TW, Dawson GR, Reynolds DS, Atack JR (Jun 2007). "Differential contribution of GABA(A) receptor subtypes to the anticonvulsant efficacy of benzodiazepine site ligands". Journal of Psychopharmacology. 21 (4): 384–91. doi:10.1177/0269881106067255. PMID 17092983. S2CID 34355306.

[1]

[2]

Identifiers

IUPAC name 5-fluoro-2-[4-fluoro-3-[8-fluoro-7-(2-hydroxypropan-2-yl)imidazo[1,2-a]pyridin-3-yl]phenyl]benzonitrile
CAS Number	628690-75-5^N
PubChem CID	9978724
ChemSpider	8154316^N
CompTox Dashboard (EPA)	DTXSID101108234
Chemical and physical data
Formula	C₂₃H₁₆F₃N₃O
Molar mass	407.396 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES N#Cc4cc(F)ccc4-c1cc(ccc1F)-c2cnc3n2ccc(C(C)(O)C)c3F
InChI InChI=1S/C23H16F3N3O/c1-23(2,30)18-7-8-29-20(12-28-22(29)21(18)26)17-10-13(3-6-19(17)25)16-5-4-15(24)9-14(16)11-27/h3-10,12,30H,1-2H3^N Key:VLFITPUZJCLTFQ-UHFFFAOYSA-N^N
^NY (what is this?) (verify)

TP-003

See also

References