Trinucleotide repeat-containing gene 6B protein is a protein that in humans is encoded by the TNRC6B gene.[5]

TNRC6B
Identifiers
AliasesTNRC6B, trinucleotide repeat containing 6B, trinucleotide repeat containing adaptor 6B, GDSBA
External IDsOMIM: 610740; MGI: 2443730; HomoloGene: 66194; GeneCards: TNRC6B; OMA:TNRC6B - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_015088
NM_001024843
NM_001162501

NM_144812
NM_177124

RefSeq (protein)

NP_001020014
NP_001155973
NP_055903

NP_659061
NP_796098

Location (UCSC)Chr 22: 40.04 – 40.34 MbChr 15: 80.6 – 80.83 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

edit

TNRC6B has been shown to interact with EIF2C2.[6] It is also known to associate with argonaute proteins and has been shown to be required for miRNA-guided gene silencing in HeLa cells.[7]

References

edit
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100354Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000047888Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: TNRC6B trinucleotide repeat containing 6B".
  6. ^ Till S, Lejeune E, Thermann R, Bortfeld M, Hothorn M, Enderle D, Heinrich C, Hentze MW, Ladurner AG (October 2007). "A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain". Nat. Struct. Mol. Biol. 14 (10): 897–903. doi:10.1038/nsmb1302. PMID 17891150. S2CID 8136380.
  7. ^ Meister G, Landthaler M, Peters L, Chen PY, Urlaub H, Lührmann R, Tuschl T (December 2005). "Identification of novel argonaute-associated proteins". Curr. Biol. 15 (23): 2149–55. doi:10.1016/j.cub.2005.10.048. hdl:11858/00-001M-0000-0012-E763-B. PMID 16289642. S2CID 2740901.

Further reading

edit