TMEM158

TMEM158
Identifiers
Aliases	TMEM158, BBP, RIS1, p40BBP, transmembrane protein 158 (gene/pseudogene), transmembrane protein 158
External IDs	MGI: 1919559; HomoloGene: 9141; GeneCards: TMEM158; OMA:TMEM158 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	45,226,287 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	123,089,829 bp
RNA expression pattern
	Top expressed in
	seminal vesicula; ; nucleus accumbens; ; putamen; ; caudate nucleus; ; ganglionic eminence; ; myometrium; ; periodontal fiber; ; tail of epididymis; ; entorhinal cortex; ; body of uterus;
	Top expressed in
	dorsal striatum; ; olfactory tubercle; ; lateral septal nucleus; ; nucleus accumbens; ; ventromedial nucleus; ; anterior amygdaloid area; ; barrel cortex; ; globus pallidus; ; supraoptic nucleus; ; gastrula;
	More reference expression data
	n/a
Orthologs
	25907
	72309
	ENSG00000249992
	ENSMUSG00000054871
	Q8WZ71
	Q6F5E0
	NM_015444
	NM_001002267
	NP_056259
	NP_001002267
	Wikidata
View/Edit Human	View/Edit Mouse

Transmembrane protein 158 is a protein that in humans is encoded by the TMEM158 gene.^[5]^[6]^[7]

Constitutive activation of the Ras pathway triggers an irreversible proliferation arrest reminiscent of replicative senescence. Transcription of this gene is upregulated in response to activation of the Ras pathway, but not under other conditions that induce senescence.

The encoded protein is similar to a rat cell surface receptor proposed to function in a neuronal survival pathway^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000249992 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000054871 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hama T, Maruyama M, Katoh-Semba R, Takizawa M, Iwashima M, Nara K (Aug 2001). "Identification and molecular cloning of a novel brain-specific receptor protein that binds to brain injury-derived neurotrophic peptide. Possible role for neuronal survival". J Biol Chem. 276 (34): 31929–35. doi:10.1074/jbc.M100617200. PMID 11399754.
^ Barradas M, Gonos ES, Zebedee Z, Kolettas E, Petropoulou C, Delgado MD, Leon J, Hara E, Serrano M (Feb 2002). "Identification of a candidate tumor-suppressor gene specifically activated during Ras-induced senescence". Exp Cell Res. 273 (2): 127–37. doi:10.1006/excr.2001.5434. PMID 11822868.
^ ^a ^b "Entrez Gene: TMEM158 transmembrane protein 158".

Iglesias D, Fernández-Peralta AM, Nejda N, et al. (2006). "RIS1, a gene with trinucleotide repeats, is a target in the mutator pathway of colorectal carcinogenesis". Cancer Genet. Cytogenet. 167 (2): 138–44. doi:10.1016/j.cancergencyto.2005.12.002. PMID 16737913.
Zirn B, Samans B, Wittmann S, et al. (2006). "Target genes of the WNT/beta-catenin pathway in Wilms tumors". Genes Chromosomes Cancer. 45 (6): 565–74. doi:10.1002/gcc.20319. PMID 16575872. S2CID 84406946.
Silva J, Silva JM, Barradas M, et al. (2006). "Analysis of the candidate tumor suppressor Ris-1 in primary human breast carcinomas". Mutat. Res. 594 (1–2): 78–85. doi:10.1016/j.mrfmmm.2005.07.017. PMID 16280139.
Sussan TE, Pletcher MT, Murakami Y, Reeves RH (2006). "Tumor suppressor in lung cancer 1 (TSLC1) alters tumorigenic growth properties and gene expression". Mol. Cancer. 4: 28. doi:10.1186/1476-4598-4-28. PMC 1208945. PMID 16083501.
Verlinden I, Janssens J, Raus J, Michiels L (2005). "Microdissection and SAGE as a combined tool to reveal gene expression in ductal carcinoma in situ of the breast". Mol. Carcinog. 41 (4): 197–206. doi:10.1002/mc.20055. PMID 15486950. S2CID 19850341.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000249992 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000054871 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11399754-5] Hama T, Maruyama M, Katoh-Semba R, Takizawa M, Iwashima M, Nara K (Aug 2001). "Identification and molecular cloning of a novel brain-specific receptor protein that binds to brain injury-derived neurotrophic peptide. Possible role for neuronal survival". J Biol Chem. 276 (34): 31929–35. doi:10.1074/jbc.M100617200. PMID 11399754.

[pmid11822868-6] Barradas M, Gonos ES, Zebedee Z, Kolettas E, Petropoulou C, Delgado MD, Leon J, Hara E, Serrano M (Feb 2002). "Identification of a candidate tumor-suppressor gene specifically activated during Ras-induced senescence". Exp Cell Res. 273 (2): 127–37. doi:10.1006/excr.2001.5434. PMID 11822868.

[entrez-7] "Entrez Gene: TMEM158 transmembrane protein 158".

[5]

[6]

[7]

[1]

[2]

[3]

[4]

TMEM158

References

Further reading