Tensin-like C1 domain-containing phosphatase is an enzyme that in humans is encoded by the TENC1 gene.[5]

TNS2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTNS2, C1-TEN, C1TEN, TENC1, tensin 2
External IDsOMIM: 607717; MGI: 2387586; HomoloGene: 37077; GeneCards: TNS2; OMA:TNS2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_015319
NM_170754
NM_198316

NM_153533
NM_001355636

RefSeq (protein)

NP_056134
NP_736610
NP_938072

NP_705761
NP_001342565

Location (UCSC)Chr 12: 53.05 – 53.06 MbChr 15: 102.01 – 102.02 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene belongs to the tensin family. Tensin is a focal adhesion molecule that binds to actin filaments and participates in signaling pathways. This protein plays a role in regulating cell migration. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.[5]

Interactions

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TENC1 has been shown to interact with AXL receptor tyrosine kinase.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000111077Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037003Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: TENC1 tensin like C1 domain containing phosphatase (tensin 2)".
  6. ^ Hafizi, Sassan; Alindri Filiz; Karlsson Roger; Dahlbäck Björn (Dec 2002). "Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin". Biochem. Biophys. Res. Commun. 299 (5). United States: 793–800. doi:10.1016/S0006-291X(02)02718-3. ISSN 0006-291X. PMID 12470648.

Further reading

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  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Tensin-2