TAL1

T-cell acute lymphocytic leukemia protein 1 (i.e. TAL1 but also termed stem cell leukemia/T-cell acute leukemia 1 [i.e. SCL/TAL1]) is a protein that in humans is encoded by the TAL1 gene.

TAL1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2YPA, 2YPB
Identifiers
Aliases	TAL1, SCL, TCL5, bHLHa17, tal-1, T-cell acute lymphocytic leukemia 1, TAL bHLH transcription factor 1, erythroid differentiation factor
External IDs	OMIM: 187040; MGI: 98480; HomoloGene: 2400; GeneCards: TAL1; OMA:TAL1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p33 Start 47,216,290 bp End 47,232,225 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4 D1|4 52.73 cM Start 114,913,623 bp End 114,928,952 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in trabecular bone monocyte bone marrow right lung endothelial cell blood upper lobe of left lung bone marrow cells buccal mucosa cell epithelium of colon Top expressed in fetal liver hematopoietic progenitor cell tibiofemoral joint blood human fetus embryo spleen endocardial cushion bone marrow yolk sac genital tubercle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding protein dimerization activity DNA-binding transcription factor activity histone deacetylase binding chromatin binding transcription cis-regulatory region binding E-box binding protein binding protein heterodimerization activity enzyme binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component histone deacetylase complex transcription regulator complex Lsd1/2 complex nucleus nucleoplasm protein-containing complex Biological process megakaryocyte development megakaryocyte differentiation myeloid cell differentiation cell fate commitment cell differentiation regulation of transcription, DNA-templated regulation of mast cell differentiation spinal cord association neuron differentiation positive regulation of protein-containing complex assembly locomotory behavior positive regulation of erythrocyte differentiation regulation of transcription by RNA polymerase II regulation of stem cell population maintenance platelet formation positive regulation of mitotic cell cycle negative regulation of transcription by RNA polymerase II transcription, DNA-templated generation of neurons basophil differentiation positive regulation of transcription, DNA-templated multicellular organism development regulation of cell population proliferation hematopoietic stem cell differentiation astrocyte fate commitment angiogenesis neuron differentiation embryonic hemopoiesis erythrocyte differentiation definitive hemopoiesis regulation of myeloid cell differentiation positive regulation of cell division hemangioblast cell differentiation positive regulation of transcription by RNA polymerase II erythrocyte maturation regulation of hematopoietic stem cell differentiation hemopoiesis transcription by RNA polymerase II negative regulation of erythrocyte differentiation positive regulation of protein tyrosine kinase activity positive regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6886 21349 Ensembl ENSG00000162367 ENSMUSG00000028717 UniProt P17542 P22091 RefSeq (mRNA) NM_001287347 NM_001290403 NM_001290404 NM_001290405 NM_001290406 NM_003189 NM_011527 NM_001287388 RefSeq (protein) NP_001274276 NP_001277332 NP_001277333 NP_001277334 NP_001277335 NP_003180 NP_001274317 NP_035657 Location (UCSC) Chr 1: 47.22 – 47.23 Mb Chr 4: 114.91 – 114.93 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by TAL1 is a basic helix-loop-helix transcription factor.

Interactions

TAL1 has been shown to interact with:

• CBFA2T3,
• EP300,
• GATA1,
• LDB1,
• LMO1,
• LMO2,
• SIN3A,
• Sp1 transcription factor, and
• TCF3.

Further reading

• Green AR, Begley CG (1993). "SCL and related hemopoietic helix-loop-helix transcription factors". Int. J. Cell Cloning. 10 (5): 269–76. doi:10.1002/stem.5530100504. PMID 1453013.
• Aplan PD, Lombardi DP, Reaman GH, Sather HN, Hammond GD, Kirsch IR (1992). "Involvement of the putative hematopoietic transcription factor SCL in T-cell acute lymphoblastic leukemia". Blood. 79 (5): 1327–33. doi:10.1182/blood.V79.5.1327.1327. PMID 1311214.
• Aplan PD, Nakahara K, Orkin SH, Kirsch IR (1992). "The SCL gene product: a positive regulator of erythroid differentiation". EMBO J. 11 (11): 4073–81. doi:10.1002/j.1460-2075.1992.tb05500.x. PMC 556917. PMID 1396592.
• Goldfarb AN, Goueli S, Mickelson D, Greenberg JM (1992). "T-cell acute lymphoblastic leukemia--the associated gene SCL/tal codes for a 42-Kd nuclear phosphoprotein". Blood. 80 (11): 2858–66. doi:10.1182/blood.V80.11.2858.bloodjournal80112858. PMID 1450410.
• Bernard O, Lecointe N, Jonveaux P, Souyri M, Mauchauffé M, Berger R, Larsen CJ, Mathieu-Mahul D (1991). "Two site-specific deletions and t(1;14) translocation restricted to human T-cell acute leukemias disrupt the 5' part of the tal-1 gene". Oncogene. 6 (8): 1477–88. PMID 1886719.
• Bernard O, Guglielmi P, Jonveaux P, Cherif D, Gisselbrecht S, Mauchauffe M, Berger R, Larsen CJ, Mathieu-Mahul D (1991). "Two distinct mechanisms for the SCL gene activation in the t(1;14) translocation of T-cell leukemias". Genes Chromosomes Cancer. 1 (3): 194–208. doi:10.1002/gcc.2870010303. PMID 1964581. S2CID 2464453.
• Chen Q, Yang CY, Tsan JT, Xia Y, Ragab AH, Peiper SC, Carroll A, Baer R (1990). "Coding sequences of the tal-1 gene are disrupted by chromosome translocation in human T cell leukemia". J. Exp. Med. 172 (5): 1403–8. doi:10.1084/jem.172.5.1403. PMC 2188666. PMID 2230650.
• Aplan PD, Begley CG, Bertness V, Nussmeier M, Ezquerra A, Coligan J, Kirsch IR (1991). "The SCL gene is formed from a transcriptionally complex locus". Mol. Cell. Biol. 10 (12): 6426–35. doi:10.1128/mcb.10.12.6426. PMC 362919. PMID 2247063.
• Chen Q, Cheng JT, Tasi LH, Schneider N, Buchanan G, Carroll A, Crist W, Ozanne B, Siciliano MJ, Baer R (1990). "The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein". EMBO J. 9 (2): 415–24. doi:10.1002/j.1460-2075.1990.tb08126.x. PMC 551682. PMID 2303035.
• Begley CG, Aplan PD, Denning SM, Haynes BF, Waldmann TA, Kirsch IR (1990). "The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motif". Proc. Natl. Acad. Sci. U.S.A. 86 (24): 10128–32. doi:10.1073/pnas.86.24.10128. PMC 298658. PMID 2602361.
• Osada H, Grutz G, Axelson H, Forster A, Rabbitts TH (1995). "Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1". Proc. Natl. Acad. Sci. U.S.A. 92 (21): 9585–9. Bibcode:1995PNAS...92.9585O. doi:10.1073/pnas.92.21.9585. PMC 40846. PMID 7568177.
• Pulford K, Lecointe N, Leroy-Viard K, Jones M, Mathieu-Mahul D, Mason DY (1995). "Expression of TAL-1 proteins in human tissues". Blood. 85 (3): 675–84. doi:10.1182/blood.V85.3.675.bloodjournal853675. PMID 7833471.
• Wadman I, Li J, Bash RO, Forster A, Osada H, Rabbitts TH, Baer R (1994). "Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia". EMBO J. 13 (20): 4831–9. doi:10.1002/j.1460-2075.1994.tb06809.x. PMC 395422. PMID 7957052.
• Valge-Archer VE, Osada H, Warren AJ, Forster A, Li J, Baer R, Rabbitts TH (1994). "The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells". Proc. Natl. Acad. Sci. U.S.A. 91 (18): 8617–21. Bibcode:1994PNAS...91.8617V. doi:10.1073/pnas.91.18.8617. PMC 44657. PMID 8078932.
• Cross MA, Heyworth CM, Murrell AM, Bockamp EO, Dexter TM, Green AR (1994). "Expression of lineage restricted transcription factors precedes lineage specific differentiation in a multipotent haemopoietic progenitor cell line". Oncogene. 9 (10): 3013–6. PMID 8084606.
• Hsu HL, Wadman I, Baer R (1994). "Formation of in vivo complexes between the TAL1 and E2A polypeptides of leukemic T cells". Proc. Natl. Acad. Sci. U.S.A. 91 (8): 3181–5. Bibcode:1994PNAS...91.3181H. doi:10.1073/pnas.91.8.3181. PMC 43539. PMID 8159721.
• Hwang LY, Siegelman M, Davis L, Oppenheimer-Marks N, Baer R (1993). "Expression of the TAL1 proto-oncogene in cultured endothelial cells and blood vessels of the spleen". Oncogene. 8 (11): 3043–6. PMID 8414504.
• Cheng JT, Cobb MH, Baer R (1993). "Phosphorylation of the TAL1 oncoprotein by the extracellular-signal-regulated protein kinase ERK1". Mol. Cell. Biol. 13 (2): 801–8. doi:10.1128/mcb.13.2.801. PMC 358963. PMID 8423803.

External links

• TAL1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• FactorBook TAL1