Synthetic ribosomes are artificial small-molecules that can synthesize peptides in a sequence-specific matter.[1]
David Alan Leigh's lab built synthetic ribosome using a chemical structure based on a rotaxane.[2]
The Cédric Orelle research group created ribosomes with tethered and inseparable subunits (or Ribo-T).[3]
References
edit- ^ Sleator, RD (2013). "Synthetic ribosomes". Bioengineered. 4 (2): 63–4. doi:10.4161/bioe.23640. PMC 3609622. PMID 23324614.
- ^ Lewandowski, B; De Bo, G; Ward, JW; Papmeyer, M; Kuschel, S; Aldegunde, MJ; Gramlich, PM; Heckmann, D; Goldup, SM; D'Souza, DM; Fernandes, AE; Leigh, DA (2013). "Sequence-specific peptide synthesis by an artificial small-molecule machine". Science. 339 (6116): 189–93. doi:10.1126/science.1229753. PMID 23307739.
- ^ Orelle, Cédric; Carlson, Erik D.; Szal, Teresa; Florin, Tanja; Jewett, Michael C.; Mankin, Alexander S. (2015). "Protein synthesis by ribosomes with tethered subunits". Nature. 524 (7563): 119–124. doi:10.1038/nature14862. PMID 26222032.