Spencer-Smith is a British double-barrelled surname. Notable people with the surname include:
- Arnold Spencer-Smith (1883–1916), English clergyman and member of Ernest Shackleton's Imperial Trans-Antarctic Expedition
- Joshua Spencer-Smith (1843–1928), English cricketer, twin brother of Orlando Spencer-Smith
- Lauren Spencer-Smith, British-born Canadian singer-songwriter
- Orlando Spencer-Smith (1843–1920), English cricketer, twin brother of Joshua Spencer-Smith