Small nucleolar RNA SNORA52

In molecular biology, Small nucleolar RNA SNORA52 (also known as ACA52) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a 'guide RNA'. ACA52 was originally cloned from HeLa cells and belongs to the H/ACA box class of snoRNAs as it has the predicted hairpin-hinge-hairpin-tail structure, has the conserved H/ACA-box motifs and is found associated with GAR1 protein. snoRNA ACA52 is predicted to guide the pseudouridylation of U3823 of 28S ribosomal RNA (rRNA). Pseudouridylation is the (isomerisation of the nucleoside uridine) to the different isomeric form pseudouridine.

Small nucleolar RNA SNORA52
Predicted secondary structure and sequence conservation of SNORA52
Identifiers
Symbol	SNORA52
Alt. Symbols	snoACA52
Rfam	RF00419
Other data
RNA type	Gene; snRNA; snoRNA; HACA-box
Domain(s)	Eukaryota
GO	GO:0006396 GO:0005730
SO	SO:0000594
PDB structures	PDBe

External links

• Page for Small nucleolar RNA SNORA52 at Rfam
• Entry for ACA52 at snoRNABase