Skuse is a surname. Notable people with the surname include:
- CJ Skuse (born 1980), English novelist and lecturer
- Cole Skuse (born 1986), English footballer
- Frederick A. Askew Skuse (c. 1863–1896), British-Australian entomologist
- Janet 'Rusty' Skuse (1943–2007), most tattooed woman in Britain
- Jean Skuse (born 1932), Australian Christian church official
- Sarah Skuse (born 1974), British entrepreneur