Sialic acid binding ig-like lectin 15

Sialic acid binding Ig-like lectin 15 (Siglec-15) is a protein that in humans is encoded by the SIGLEC15 gene.[5] Siglec-15 is predominately expressed on osteoclasts, elevated levels of Siglec- 15 in the bone metastatic niche can promote tumor-induced osteoclastogenesis as well as suppress antigen-specific T cell responses. Researchers demonstrated that antibody blockade of the Siglec-15/sialic acid glycol-immune checkpoint axis can act as a potential treatment for breast cancer bone metastasis.[6]

SIGLEC15
Identifiers
AliasesSIGLEC15, CD33L3, HsT1361, SIGLEC-15, Sialic acid binding ig-like lectin 15, sialic acid binding Ig like lectin 15
External IDsOMIM: 618105; MGI: 3646642; HomoloGene: 52643; GeneCards: SIGLEC15; OMA:SIGLEC15 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_213602

NM_001101038

RefSeq (protein)

NP_998767

NP_001094508

Location (UCSC)Chr 18: 45.83 – 45.84 MbChr 18: 78.09 – 78.1 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000197046Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000091055Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Sialic acid binding Ig-like lectin 15".
  6. ^ Wang Y, Zhan X, et al. (January 22, 2024). "Siglec-15/sialic acid axis as a central glyco-immune checkpoint in breast cancer bone metastasis". Proceedings of the National Academy of Sciences of the United States of America. 121 (5): e2312929121. doi:10.1073/pnas.2312929121. PMC 10835054. PMID 38252825.

Further reading

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