In the field of neurology, seizure types are categories of seizures defined by seizure behavior, symptoms, and diagnostic tests. The International League Against Epilepsy (ILAE) 2017 classification of seizures is the internationally recognized standard for identifying seizure types.[1] The ILAE 2017 classification of seizures is a revision of the prior ILAE 1981 classification of seizures.[2] Distinguishing between seizure types is important since different types of seizures may have different causes, outcomes, and treatments.
History
editIn ~2500 B.C., the Sumerians provided the first writings about seizures.[3]: 458 Later in ~1050 B.C., the Babylonian scholars developed the first seizure classification, inscribing their medical knowledge in the stone tablets called Sakikku or in English "All Diseases."[3]: 458 This early classification identified febrile seizures, absence seizures, generalized tonic-clonic seizures, focal seizures, impaired awareness seizures, and status epilepticus.[3]: 458 Samuel-Auguste Tissot (1728–1797) authored Traité de l’Epilepsie, a book describing grand état (generalized tonic-clonic seizures) and petit état (absence seizures).[3]: 460 Jean-Étienne Dominique Esquirol (1772–1840) later introduced grand mal (generalized tonic-clonic seizures) and petit mal to describe these seizures.[3]: 460 In 1937, Gibbs and Lennox introduced psychomotor seizures, seizures with "mental, emotional, motor, and autonomic phenomena."[4] Henri Gastaut led the effort to develop the ILAE 1969 classification of seizures based on clinical seizure type, electroencephalogram (EEG), anatomical substrate, etiology, and age of onset.[2]: 491 The ILAE 1981 classification of seizure included information from EEG-video seizure recordings, but excluded anatomical substrate, etiology, and age factors as these factors were "historical or speculative" rather than directly observed.[2]: 491 The ILAE 2017 classification of seizures closely reflects clinical practice, using observed seizure behavior and additional data to identify seizure types.[1]: 523
Focal vs. generalized seizure onset
editA seizure is a paroxysmal episode of symptoms or altered behavior arising from abnormal excessive or synchronous brain neuronal activity.[5] A focal onset seizure arises from a biological neural network within one cerebral hemisphere, while a generalized onset seizure arises from within the cerebral hemispheres rapidly involving both hemispheres.[1]: 526 Seizure symptoms, seizure behavior, neuroimaging, seizure etiology, EEG, and video recordings help distinguish focal from generalized onset seizures.[1]: 526 Unknown onset seizures occur if the available information is insufficient to distinguish focal from generalized onset seizures with a confidence.[1]: 524, 527 Focal to bilateral tonic-clonic seizure indicates that the seizure begins as focal seizure then later evolves to a bilateral tonic-clonic seizure.[1]: 525
Aware vs. impaired awareness
editThe classification distinguishes focal aware seizures from focal impaired awareness seizures.[1]: 524 Aware means aware of self and surroundings during the seizure, verified when a person can recall events having occurred during the seizure.[1]: 527 Impaired awareness occurs even if the recall of events is only partially impaired.[1] Impaired awareness may occur at any time during the seizure.[1] If the level of awareness cannot be determined, the level of awareness is unspecified; this usually occurs for atonic seizures and epileptic spasm seizures.[1]: 525
Motor seizures
editA motor seizure has prominent movement, increased muscle contraction, or decreased muscle contraction as the initial predominant seizure feature.[1] Atonic seizures are a brief 0.5-2 second lapses in muscle tone commonly leading to a fall.[6] Epileptic spasm seizures are brief 1-2 second proximal limb and truncal flexion or extension movements, often repeated.[6] Hyperkinetic seizures occur as high amplitude truncal and limb movements such as pedaling, thrashing, and rocking movements.[7] Myoclonic seizures are brief jerks of limbs or body lasting milliseconds.[6] Tonic seizures are abrupt increases in muscle tone greater than 2 seconds in duration.[6] Clonic seizures occur as rhythmic body jerks.[7] Myoclonic-atonic seizures begins with one or more jerks (myoclonic phase) followed by a loss of muscle tone (atonic phase).[6] Myoclonic-tonic-clonic seizures begin with one or more jerks (myoclonic phase), then body stiffening (tonic-phase), then rhythmic jerks (clonic phase).[6] Tonic-clonic seizures begin as symmetrical bilateral body stiffening (tonic phase) followed by rhythmic jerks (clonic phase).[6] Myoclonic, atonic, tonic, and myoclonic-atonic seizures may cause abrupt falls, called drop attacks, similar to cataplexy.[8] Automatism seizures occur with repetitive stereotyped behaviors.
| Type | Repeated stereotyped behaviors |
|---|---|
| Orofacial | lip smacking, chewing or swallowing movements |
| Manual | hand tapping, fumbling, rubbing or picking movements |
| Leg | walking, running, pacing |
| Perseverative | pre-seizure behavior continues during the seizure |
| Sexual | sexual behaviors |
| Vocal | vocalizations |
| Verbal | spoken words |
Non-motor seizures
editA non-motor seizure may begin with a sensory, cognitive, autonomic, or emotional symptom, behavioral arrest of activity, or impaired awareness with minor motor activity as the initial predominant seizure feature.[1]
Sensory seizures occur with somatosensory, olfactory, visual, gustatory, vestibular, or thermal sensations.[9] Cognitive seizures occur with language impairment (e.g. aphasia, dysphasia, anomia), memory impairments (deja vu, jamais vu), hallucinations, persistent thought (forced thinking), and neglect.[9] Autonomic seizures occur with palpitations, heart rate changes, nausea, vomiting, piloerection, lacrimation, pupil size changes or urge to urinate or defecate.[9] Emotional seizures occur with fear, anxiety, laughing, crying, pleasure, or anger sensations.[9] These initial symptoms are seizure auras.[10] Behavioral arrest seizures occur as an abrupt cessation of movement.[9]
Absence seizures occur with a sudden brief impairment in awareness, commonly less than 45 seconds.[6] Typical absence seizures may be accompanied by rhythmic facial 3 per second facial movements.[6] Atypical absence seizures occur with a less sudden impairment in awareness, often accompanied by a gradual head, limb, or truncal slumping.[6] Myoclonic absence seizures occur with myoclonic jerks of arms and shoulders.[6] Absence with eyelid myoclonia seizures occur with 4-6 per second eyelid myoclonic jerks and upward eye movement.[6]
Descriptors
editDescriptors are additional seizure behaviors or symptoms that are appended to the seizure diagnosis. Descriptors may be a non-predominant or non-initial seizure feature.[1] Descriptors provide a more complete description of the seizure.[1]
ILAE 2017 classification of seizure types
edit| Focal onset1
Motor onset
Non-motor onset.
|
Generalized onset
Motor onset
Non-motor onset (Absence)
|
Unknown onset
Motor onset
Non-motor onset
Unclassified |
1 - Classify focal seizures as focal aware, focal impaired awareness, or focal unspecified awareness.[1]: 525
Examples
editFocal onset seizure
editDuring the typical 1 minute seizure, a person experiences a familiar (déjà vu) sensation, followed by picking and fumbling hand movements. After this seizure, the person cannot recall what was said during the seizure. Brain magnetic resonance imaging (MRI) shows left hippocampal sclerosis, a brain abnormality associated with focal seizures.[11] This is a focal impaired awareness cognitive seizure with déjà vu. Appending a descriptor, this is a focal impaired awareness cognitive seizure with déjà vu followed by hand automatisms.
Generalized onset seizure
editDuring the typical 10 second seizure, a child abruptly stops and stares with 3 per second rhythmic eye fluttering movements. After the seizure, the child cannot recall what occurred during the seizure. An EEG test shows 3 per second spike-wave pattern, an EEG pattern indicating a generalized onset seizure. This generalized onset non-motor (absence) seizure is a typical absence seizure. Appending a descriptor, this is a typical absence seizure with 3 per second eye fluttering movements.
Comparison of ILAE 2017 and ILAE 1981 classifications
editDyscognitive, simple partial, complex partial, psychic, and secondarily generalized are terms that apply only to the ILAE 1981 classification of seizures.[1]: 525 The ILAE 2017 classification relies on intact awareness of self and surroundings, but the ILAE 1981 classification relies on intact consciousness, defined as a normal response to an external stimulus due to intact awareness and intact ability to respond.[2]: 493 [1]: 525 Unlike the ILAE 2017 classification, the ILAE 1981 classification specifies specific EEG patterns for each seizure type.[2]: 493–495
| ILAE 2017 | ILAE 1981 |
|---|---|
| Focal seizure | Partial seizure |
| Generalized seizure | Generalized seizure |
| Focal aware seizure | Simple partial seizure |
| Focal impaired awareness seizure | Complex partial seizure |
| Non-motor seizure | Non-convulsive seizure |
| Motor seizure | Convulsive seizure |
| Cognitive seizure | Psychic seizure |
| Emotional seizure | Affective seizure |
| Focal to bilateral tonic-clonic seizure | Secondary generalized tonic-clonic seizure |
ILAE 1981 classification of seizure types
editThe associated EEG patterns are not included.[2]: 493
Partial seizures.[2]: 493
- Simple partial seizures: consciousness is not impaired.
- With motor signs
- With somatosensory or special-sensory symptoms
- With autonomic symptoms or signs
- With psychic symptoms
- Complex partial seizures: consciousness is impaired.
- Simple partial onset, followed by impairment of consciousness
- With impairment of consciousness at onset
- Partial seizures evolving to secondarily generalized seizures
- Simple partial seizures evolving to generalized seizures
- Complex partial seizures evolving to generalized seizures
- Simple partial seizures evolving to complex partial seizures evolving to generalized seizures
Generalized seizures.[2]: 493
- Absence seizures
- Absence seizures
- Atypical absence seizures
- Myoclonic seizures
- Clonic seizures
- Tonic seizures
- Tonic-clonic seizures
- Atonic seizures
Unclassified epileptic seizures
Continuous and subclinical seizures
editStatus epilepticus is a seizure "lasting longer than 30 minutes or a series of seizures without return to the baseline level of alertness between seizures."[12]
Epilepsia partialis continua is a rare type of focal motor seizure, commonly involving the hands or face, which recurs with intervals of seconds or minutes, lasting for extended periods of days or years.[13] Common causes are strokes in adults, and focal cortical inflammation in children: Rasmussen's encephalitis, chronic viral infections, or autoimmune encephalitis.[13]
Subclinical seizures cause no symptoms and either no altered behavior or very minimal behavioral changes; the clinician recognizes these seizures as an evolving seizure pattern on an EEG recording.[14][15]
Based on unusual symptoms
editSome forms of seizures have been defined based on symptoms, such as ecstatic seizures and orgasmic seizures.[16][17]
Citations
edit- ^ a b c d e f g h i j k l m n o p q r Fisher et al. 2017.
- ^ a b c d e f g h i Bancaud et al. 1981.
- ^ a b c d e Panteliadis et al. 2017.
- ^ Vannemreddy et al. 2010.
- ^ Fisher et al. 1981.
- ^ a b c d e f g h i j k l International League Against Epilepsy 2022a, Generalized onset seizure.
- ^ a b c International League Against Epilepsy 2022b, Motor seizure.
- ^ International League Against Epilepsy 2022c, Epilepsy imitators.
- ^ a b c d e International League Against Epilepsy 2022d, Focal onset seizure.
- ^ International League Against Epilepsy 2022e, Sensory seizure.
- ^ Varoglu et al. 2009.
- ^ Abend et al. 2014.
- ^ a b Mameniškienė & Wolf 2017.
- ^ Jin et al. 2017.
- ^ Freund, Probasco & Ritzl 2018.
- ^ Gschwind M, Picard F (2016). "Ecstatic Epileptic Seizures: A Glimpse into the Multiple Roles of the Insula". Front Behav Neurosci. 10: 21. doi:10.3389/fnbeh.2016.00021. PMC 4756129. PMID 26924970.
- ^ Arias M (2019). "Neurology of ecstatic religious and similar experiences: Ecstatic, orgasmic, and musicogenic seizures. Stendhal syndrome and autoscopic phenomena". Neurologia (Engl Ed). 34 (1): 55–61. doi:10.1016/j.nrl.2016.04.010. PMID 27340019.
References
edit- Abend, Nicholas S.; Bearden, David; Helbig, Ingo; McGuire, Jennifer; et al. (2014). "Status Epilepticus and Refractory Status Epilepticus Management". Seminars in Pediatric Neurology. 21 (4): 263–274. doi:10.1016/j.spen.2014.12.006. PMC 4346709. PMID 25727508.
- Bancaud, Jean; Henriksen, Olaf; Rubio-Donnadieu, Francisco; Seino, Masakatsu; et al. (1981). "Proposal for revised clinical and electroencephalographic classification of epileptic seizures. From the Commission on Classification and Terminology of the International League Against Epilepsy". Epilepsia. 22 (4): 489–501. doi:10.1111/j.1528-1157.1981.tb06159.x. PMID 6790275. S2CID 22190102.
- Fisher, Robert S.; Boas, W.V.; Blume, Warren; Elger, Christian; et al. (April 2005). "Epileptic Seizures and Epilepsy: Definitions Proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE)". Epilepsia. 46 (4): 470–472. doi:10.1111/j.0013-9580.2005.66104.x. PMID 15816939.
- Fisher, RS; Cross, JH; French, JA; Higurashi, N; et al. (April 2017). "Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology". Epilepsia. 58 (4): 522–530. doi:10.1111/epi.13670. hdl:11343/292620. PMID 28276060.
- Freund, Brin; Probasco, John C.; Ritzl, Eva K. (2018). "Seizure incidence in the acute postneurosurgical period diagnosed using continuous electroencephalography". Journal of Neurosurgery. 130 (4): 1203–1209. doi:10.3171/2018.1.JNS171466. ISSN 1933-0693. PMID 30067470.
- Gastaut H (1970). "Clinical and electroencephalographical classification of epileptic seizures". Epilepsia. 11 (1): 102–13. doi:10.1111/j.1528-1157.1970.tb03871.x. PMID 5268244. S2CID 39230273.
- Jin, Bo; Wang, Shan; Yang, Linglin; Shen, Chunhong; et al. (2017). "Prevalence and predictors of subclinical seizures during scalp video-EEG monitoring in patients with epilepsy". International Journal of Neuroscience. 127 (8): 651–658. doi:10.1080/00207454.2016.1220946. ISSN 0020-7454. PMID 27569054. S2CID 3673303.
- International League Against Epilepsy (2022a). "EpilepsyDiagnosis.org". www.epilepsydiagnosis.org. Retrieved 1 May 2023.
- International League Against Epilepsy (2022b). "EpilepsyDiagnosis.org". Retrieved 1 May 2023.
- International League Against Epilepsy (2022c). "EpilepsyDiagnosis.org". Retrieved 1 May 2023.
- International League Against Epilepsy (2022d). "EpilepsyDiagnosis.org". Retrieved 1 May 2023.
- International League Against Epilepsy (2022e). "EpilepsyDiagnosis.org". Retrieved 1 May 2023.
- Mameniškienė, Rūta; Wolf, Peter (2017). "Epilepsia partialis continua: A review". Seizure. 44: 74–80. doi:10.1016/j.seizure.2016.10.010. PMID 28029552.
- Patel, Puja; Moshé, Solomon L. (2020). "The evolution of the concepts of seizures and epilepsy: What's in a name?". Epilepsia Open. 5 (1): 22–35. doi:10.1002/epi4.12375. PMC 7049807. PMID 32140641.
- Panteliadis, Christos P.; Vassilyadi, Photios; Fehlert, Julia; Hagel, Christian (2017). "Historical documents on epilepsy: From antiquity through the 20th century". Brain and Development. 39 (6): 457–463. doi:10.1016/j.braindev.2017.02.002. PMID 28249737.
- Vannemreddy, Prasad; Stone, JamesL; Vannemreddy, Siddharth; Slavin, KonstantinV (2010). "Psychomotor seizures, Penfield, Gibbs, Bailey and the development of anterior temporal lobectomy: A historical vignette". Annals of Indian Academy of Neurology. 13 (2): 103–107. doi:10.4103/0972-2327.64630. PMC 2924506. PMID 20814492.
- Varoglu, Asuman Orhan; Saygi, Serap; Acemoglu, Hamit; Ciger, Abdurrahman (2009). "Prognosis of patients with mesial temporal lobe epilepsy due to hippocampal sclerosis". Epilepsy Research. 85 (2–3): 206–211. doi:10.1016/j.eplepsyres.2009.03.001. PMID 19345070.
- Wilson, J.V. Kinnier; Reynolds, E.H. (1990). "Texts and documents. Translation and analysis of a cuneiform text forming part of a Babylonian treatise on epilepsy". Med Hist. 34 (2): 185–98. doi:10.1017/s0025727300050651. PMC 1036070. PMID 2187129.