The Schuyler sisters can refer to:
- historical Schuyler sisters of the prominent American Schuyler family:
- Angelica Schuyler Church (1756–1814), American socialite
- Elizabeth Schuyler Hamilton (1757–1854), American socialite and philanthropist, wife of Alexander Hamilton
- Peggy Schuyler (1758–1801), American socialite
- "The Schuyler Sisters", a song from the musical Hamilton