STX5

Syntaxin-5 is a protein that in humans is encoded by the STX5 gene.

STX5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3EFO
Identifiers
Aliases	STX5, SED5, STX5A, syntaxin 5
External IDs	OMIM: 603189; MGI: 1928483; HomoloGene: 2381; GeneCards: STX5; OMA:STX5 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11q12.3 Start 62,806,860 bp End 62,832,051 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band 19|19 A Start 8,718,777 bp End 8,733,433 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bone marrow cells blood granulocyte body of pancreas olfactory zone of nasal mucosa canal of the cervix ectocervix left ovary left lobe of thyroid gland prostate Top expressed in primary oocyte internal carotid artery external carotid artery fossa condyle secondary oocyte lacrimal gland vas deferens pituitary gland islet of Langerhans More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein N-terminus binding protein binding SNARE binding SNAP receptor activity cadherin binding Cellular component integral component of membrane vesicle endoplasmic reticulum membrane membrane endoplasmic reticulum ER to Golgi transport vesicle membrane SNARE complex endoplasmic reticulum-Golgi intermediate compartment membrane Golgi apparatus cytosol Golgi membrane endomembrane system Biological process positive regulation of protein catabolic process vesicle fusion with Golgi apparatus early endosome to Golgi transport vesicle docking COPII vesicle coating regulation of Golgi organization retrograde transport, endosome to Golgi Golgi disassembly vesicle fusion vesicle-mediated transport intracellular protein transport endoplasmic reticulum to Golgi vesicle-mediated transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6811 56389 Ensembl ENSG00000162236 ENSMUSG00000010110 UniProt Q13190 Q8K1E0 RefSeq (mRNA) NM_001244666 NM_003164 NM_001330294 NM_001167799 NM_019829 RefSeq (protein) NP_001231595 NP_001317223 NP_003155 NP_001161271 NP_062803 Location (UCSC) Chr 11: 62.81 – 62.83 Mb Chr 19: 8.72 – 8.73 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Interactions

STX5 has been shown to interact with:

• BET1L,
• GOSR1,
• GOSR2,
• NAPA, and
• USO1.

Further reading

• Nichols BJ, Pelham HR (Aug 1998). "SNAREs and membrane fusion in the Golgi apparatus". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1404 (1–2): 9–31. doi:10.1016/S0167-4889(98)00044-5. PMID 9714710.
• Hay JC, Chao DS, Kuo CS, Scheller RH (Apr 1997). "Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells". Cell. 89 (1): 149–58. doi:10.1016/S0092-8674(00)80191-9. PMID 9094723. S2CID 8682509.
• Paek I, Orci L, Ravazzola M, Erdjument-Bromage H, Amherdt M, Tempst P, Söllner TH, Rothman JE (Jun 1997). "ERS-24, a mammalian v-SNARE implicated in vesicle traffic between the ER and the Golgi". The Journal of Cell Biology. 137 (5): 1017–28. doi:10.1083/jcb.137.5.1017. PMC 2136225. PMID 9166403.
• Rabouille C, Kondo H, Newman R, Hui N, Freemont P, Warren G (Mar 1998). "Syntaxin 5 is a common component of the NSF- and p97-mediated reassembly pathways of Golgi cisternae from mitotic Golgi fragments in vitro". Cell. 92 (5): 603–10. doi:10.1016/S0092-8674(00)81128-9. PMID 9506515. S2CID 17285800.
• Hay JC, Klumperman J, Oorschot V, Steegmaier M, Kuo CS, Scheller RH (Jun 1998). "Localization, dynamics, and protein interactions reveal distinct roles for ER and Golgi SNAREs". The Journal of Cell Biology. 141 (7): 1489–502. doi:10.1083/jcb.141.7.1489. PMC 2133002. PMID 9647643.
• Martín-Martín B, Nabokina SM, Lazo PA, Mollinedo F (Mar 1999). "Co-expression of several human syntaxin genes in neutrophils and differentiating HL-60 cells: variant isoforms and detection of syntaxin 1". Journal of Leukocyte Biology. 65 (3): 397–406. doi:10.1002/jlb.65.3.397. hdl:10261/59829. PMID 10080545. S2CID 18988377.
• Xu D, Joglekar AP, Williams AL, Hay JC (Dec 2000). "Subunit structure of a mammalian ER/Golgi SNARE complex". The Journal of Biological Chemistry. 275 (50): 39631–9. doi:10.1074/jbc.M007684200. PMID 11035026.
• Shorter J, Beard MB, Seemann J, Dirac-Svejstrup AB, Warren G (Apr 2002). "Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115". The Journal of Cell Biology. 157 (1): 45–62. doi:10.1083/jcb.200112127. PMC 2173270. PMID 11927603.
• Xu Y, Martin S, James DE, Hong W (Oct 2002). "GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus". Molecular Biology of the Cell. 13 (10): 3493–507. doi:10.1091/mbc.E02-01-0004. PMC 129961. PMID 12388752.
• Uchiyama K, Jokitalo E, Kano F, Murata M, Zhang X, Canas B, Newman R, Rabouille C, Pappin D, Freemont P, Kondo H (Dec 2002). "VCIP135, a novel essential factor for p97/p47-mediated membrane fusion, is required for Golgi and ER assembly in vivo". The Journal of Cell Biology. 159 (5): 855–66. doi:10.1083/jcb.200208112. PMC 2173386. PMID 12473691.
• Dulubova I, Yamaguchi T, Arac D, Li H, Huryeva I, Min SW, Rizo J, Sudhof TC (Jan 2003). "Convergence and divergence in the mechanism of SNARE binding by Sec1/Munc18-like proteins". Proceedings of the National Academy of Sciences of the United States of America. 100 (1): 32–7. Bibcode:2003PNAS..100...32D. doi:10.1073/pnas.232701299. PMC 140874. PMID 12506202.
• Williams AL, Ehm S, Jacobson NC, Xu D, Hay JC (Jan 2004). "rsly1 binding to syntaxin 5 is required for endoplasmic reticulum-to-Golgi transport but does not promote SNARE motif accessibility". Molecular Biology of the Cell. 15 (1): 162–75. doi:10.1091/mbc.E03-07-0535. PMC 307537. PMID 14565970.
• Hirose H, Arasaki K, Dohmae N, Takio K, Hatsuzawa K, Nagahama M, Tani K, Yamamoto A, Tohyama M, Tagaya M (Mar 2004). "Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi". The EMBO Journal. 23 (6): 1267–78. doi:10.1038/sj.emboj.7600135. PMC 381410. PMID 15029241.
• Suga K, Tomiyama T, Mori H, Akagawa K (Aug 2004). "Syntaxin 5 interacts with presenilin holoproteins, but not with their N- or C-terminal fragments, and affects beta-amyloid peptide production". The Biochemical Journal. 381 (Pt 3): 619–28. doi:10.1042/BJ20040618. PMC 1133870. PMID 15109302.
• Tai G, Lu L, Wang TL, Tang BL, Goud B, Johannes L, Hong W (Sep 2004). "Participation of the syntaxin 5/Ykt6/GS28/GS15 SNARE complex in transport from the early/recycling endosome to the trans-Golgi network". Molecular Biology of the Cell. 15 (9): 4011–22. doi:10.1091/mbc.E03-12-0876. PMC 515336. PMID 15215310.