STK25

Serine/threonine-protein kinase 25 is an enzyme that in humans is encoded by the STK25 gene.

STK25
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2XIK, 3W8H, 4NZW
Identifiers
Aliases	STK25, SOK1, YSK1, serine/threonine kinase 25
External IDs	OMIM: 602255; MGI: 1891699; HomoloGene: 48428; GeneCards: STK25; OMA:STK25 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q37.3 Start 241,492,670 bp End 241,509,730 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1 D|1 47.25 cM Start 93,547,473 bp End 93,586,381 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle of thigh right lobe of thyroid gland right hemisphere of cerebellum gastrocnemius muscle left lobe of thyroid gland right frontal lobe apex of heart ventricular zone anterior pituitary ganglionic eminence Top expressed in spermatocyte dentate gyrus of hippocampal formation granule cell neural layer of retina spermatid superior frontal gyrus ventricular zone genital tubercle muscle of thigh right ventricle tail of embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity protein kinase activity nucleotide binding protein homodimerization activity metal ion binding kinase activity protein binding ATP binding protein serine/threonine kinase activity MAP kinase kinase kinase kinase activity Cellular component cytoplasm Golgi apparatus Golgi membrane extracellular exosome Biological process intrinsic apoptotic signaling pathway in response to hydrogen peroxide phosphorylation response to oxidative stress positive regulation of axonogenesis establishment of Golgi localization Golgi reassembly establishment or maintenance of cell polarity protein phosphorylation Golgi localization protein autophosphorylation response to hydrogen peroxide signal transduction positive regulation of stress-activated MAPK cascade MAPK cascade regulation of mitotic cell cycle regulation of apoptotic process neuron projection morphogenesis stress-activated protein kinase signaling cascade activation of protein kinase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10494 59041 Ensembl ENSG00000115694 ENSMUSG00000026277 UniProt O00506 Q9Z2W1 RefSeq (mRNA) NM_001271977 NM_001271978 NM_001271979 NM_001271980 NM_001282305 NM_001282306 NM_001282307 NM_001282308 NM_006374 NM_021537 RefSeq (protein) NP_001258906 NP_001258907 NP_001258908 NP_001258909 NP_001269234 NP_001269235 NP_001269236 NP_001269237 NP_006365 NP_067512 Location (UCSC) Chr 2: 241.49 – 241.51 Mb Chr 1: 93.55 – 93.59 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Interactions

STK25 has been shown to interact with STRN, PDCD10 and MOBKL3.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Findlay GM, Yan L, Procter J, et al. (2007). "A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling". Biochem. J. 403 (1): 13–20. doi:10.1042/BJ20061881. PMC 1828895. PMID 17253963.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Matsuki T, Matthews RT, Cooper JA, van der Brug MP, Cookson MR, Hardy JA, Olson EC, Howell BW (November 2010). "Reelin and stk25 have opposing roles in neuronal polarization and dendritic Golgi deployment". Cell. 143 (5): 826–36. doi:10.1016/j.cell.2010.10.029. PMC 3033572. PMID 21111240.