SR-17018

SR-17018
Identifiers
	IUPAC name 5,6-dichloro-3-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-1H-benzimidazol-2-one;
CAS Number	2134602-45-0 ;
PubChem CID	130431397;
ChemSpider	67886365;
UNII	2M8P7UAW4W;
ChEMBL	ChEMBL4452384;
PDB ligand	WH9 (PDBe, RCSB PDB);
CompTox Dashboard (EPA)	DTXSID101336689 ;
Chemical and physical data
Formula	C19H18Cl3N3O
Molar mass	410.72 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1CN(CCC1N2C3=CC(=C(C=C3NC2=O)Cl)Cl)CC4=CC=C(C=C4)Cl;
	InChI InChI=1S/C19H18Cl3N3O/c20-13-3-1-12(2-4-13)11-24-7-5-14(6-8-24)25-18-10-16(22)15(21)9-17(18)23-19(25)26/h1-4,9-10,14H,5-8,11H2,(H,23,26); Key:LAGUDYUGRSQDKS-UHFFFAOYSA-N;

SR-17018 is a drug which acts as a biased agonist at the μ-opioid receptor, selective for activation of the G-protein signalling pathway over β-arrestin 2 recruitment.^[1] In animal studies it produces analgesic effects but with less respiratory depression and development of tolerance than conventional opioids.^[2]^[3]^[4]^[5]

References

^ Schmid CL, Kennedy NM, Ross NC, Lovell KM, Yue Z, Morgenweck J, Cameron MD, Bannister TD, Bohn LM. Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics. Cell. 2017 Nov 16;171(5):1165-1175.e13. doi: 10.1016/j.cell.2017.10.035. PMID: 29149605; PMCID: PMC5731250.
^ Grim TW, Schmid CL, Stahl EL, Pantouli F, Ho JH, Acevedo-Canabal A, et al. (January 2020). "A G protein signaling-biased agonist at the μ-opioid receptor reverses morphine tolerance while preventing morphine withdrawal". Neuropsychopharmacology. 45 (2): 416–425. doi:10.1038/s41386-019-0491-8. PMC 6901606. PMID 31443104.
^ Grim TW, Acevedo-Canabal A, Bohn LM. Toward Directing Opioid Receptor Signaling to Refine Opioid Therapeutics. Biol Psychiatry. 2020 Jan 1;87(1):15-21. doi: 10.1016/j.biopsych.2019.10.020. Epub 2019 Oct 31. PMID: 31806082; PMCID: PMC6919561.}
^ Podlewska S, Bugno R, Kudla L, Bojarski AJ, Przewlocki R (October 2020). "Molecular Modeling of µ Opioid Receptor Ligands with Various Functional Properties: PZM21, SR-17018, Morphine, and Fentanyl-Simulated Interaction Patterns Confronted with Experimental Data". Molecules. 25 (20): 4636. doi:10.3390/molecules25204636. PMC 7594085. PMID 33053718.
^ Pantouli F, Grim TW, Schmid CL, Acevedo-Canabal A, Kennedy NM, Cameron MD, et al. (December 2020). "Comparison of morphine, oxycodone and the biased MOR agonist SR-17018 for tolerance and efficacy in mouse models of pain". Neuropharmacology. 185: 108439. doi:10.1016/j.neuropharm.2020.108439. PMC 7887086. PMID 33345829. S2CID 229306872.

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[1] Schmid CL, Kennedy NM, Ross NC, Lovell KM, Yue Z, Morgenweck J, Cameron MD, Bannister TD, Bohn LM. Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics. Cell. 2017 Nov 16;171(5):1165-1175.e13. doi: 10.1016/j.cell.2017.10.035. PMID: 29149605; PMCID: PMC5731250.

[2] Grim TW, Schmid CL, Stahl EL, Pantouli F, Ho JH, Acevedo-Canabal A, et al. (January 2020). "A G protein signaling-biased agonist at the μ-opioid receptor reverses morphine tolerance while preventing morphine withdrawal". Neuropsychopharmacology. 45 (2): 416–425. doi:10.1038/s41386-019-0491-8. PMC 6901606. PMID 31443104.

[3] Grim TW, Acevedo-Canabal A, Bohn LM. Toward Directing Opioid Receptor Signaling to Refine Opioid Therapeutics. Biol Psychiatry. 2020 Jan 1;87(1):15-21. doi: 10.1016/j.biopsych.2019.10.020. Epub 2019 Oct 31. PMID: 31806082; PMCID: PMC6919561.}

[4] Podlewska S, Bugno R, Kudla L, Bojarski AJ, Przewlocki R (October 2020). "Molecular Modeling of µ Opioid Receptor Ligands with Various Functional Properties: PZM21, SR-17018, Morphine, and Fentanyl-Simulated Interaction Patterns Confronted with Experimental Data". Molecules. 25 (20): 4636. doi:10.3390/molecules25204636. PMC 7594085. PMID 33053718.

[5] Pantouli F, Grim TW, Schmid CL, Acevedo-Canabal A, Kennedy NM, Cameron MD, et al. (December 2020). "Comparison of morphine, oxycodone and the biased MOR agonist SR-17018 for tolerance and efficacy in mouse models of pain". Neuropharmacology. 185: 108439. doi:10.1016/j.neuropharm.2020.108439. PMC 7887086. PMID 33345829. S2CID 229306872.

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Identifiers

IUPAC name 5,6-dichloro-3-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-1H-benzimidazol-2-one
CAS Number	2134602-45-0^Y
PubChem CID	130431397
ChemSpider	67886365
UNII	2M8P7UAW4W
ChEMBL	ChEMBL4452384
PDB ligand	WH9 (PDBe, RCSB PDB)
CompTox Dashboard (EPA)	DTXSID101336689
Chemical and physical data
Formula	C₁₉H₁₈Cl₃N₃O
Molar mass	410.72 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C1CN(CCC1N2C3=CC(=C(C=C3NC2=O)Cl)Cl)CC4=CC=C(C=C4)Cl
InChI InChI=1S/C19H18Cl3N3O/c20-13-3-1-12(2-4-13)11-24-7-5-14(6-8-24)25-18-10-16(22)15(21)9-17(18)23-19(25)26/h1-4,9-10,14H,5-8,11H2,(H,23,26) Key:LAGUDYUGRSQDKS-UHFFFAOYSA-N

SR-17018

See also

References