Spinster homolog 2 (Drosophila) is a protein that in humans is encoded by the SPNS2 gene .[ 5]
The orthologous protein in zebrafish has been shown to transport sphingosine-1-phosphate (S1P) out of cells during vascular development, and human SPNS2 can transport S1P analogues, including the immunomodulating drug FTY720-P.[ 6] [ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000183018 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040447 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Spinster homolog 2 (Drosophila)" . Retrieved 2011-12-04 .^ Kawahara A, Nishi T, Hisano Y, Fukui H, Yamaguchi A, Mochizuki N (January 2009). "The sphingolipid transporter spns2 functions in migration of zebrafish myocardial precursors" . Science . 323 (5913): 524–7. Bibcode :2009Sci...323..524K . doi :10.1126/science.1167449 PMID 19074308 . S2CID 44826764 . ^ Hisano Y, Kobayashi N, Kawahara A, Yamaguchi A, Nishi T (January 2011). "The sphingosine 1-phosphate transporter, SPNS2, functions as a transporter of the phosphorylated form of the immunomodulating agent FTY720" . The Journal of Biological Chemistry . 286 (3): 1758–66. doi :10.1074/jbc.M110.171116 PMC 3023470 PMID 21084291 .
