SLC2A10

Solute carrier family 2, facilitated glucose transporter member 10 is a protein that in humans is encoded by the SLC2A10 gene.

SLC2A10
Identifiers
Aliases	SLC2A10, ATS, GLUT10, solute carrier family 2 member 10, ATORS
External IDs	OMIM: 606145; MGI: 2156687; HomoloGene: 38551; GeneCards: SLC2A10; OMA:SLC2A10 - orthologs
Gene location (Human) Chr. Chromosome 20 (human) Band 20q13.12 Start 46,709,649 bp End 46,736,347 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2 H3|2 85.66 cM Start 165,345,707 bp End 165,361,837 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia bronchial epithelial cell stromal cell of endometrium palpebral conjunctiva Epithelium of choroid plexus decidua olfactory zone of nasal mucosa right lobe of liver prostate nasal epithelium Top expressed in pyloric antrum epithelium of stomach ascending aorta aortic valve mucous cell of stomach calvaria secondary oocyte vestibular membrane of cochlear duct body of femur primary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function glucose transmembrane transporter activity carbohydrate:proton symporter activity transmembrane transporter activity transporter activity D-glucose transmembrane transporter activity Cellular component perinuclear region of cytoplasm integral component of membrane plasma membrane membrane endomembrane system cytoplasm integral component of plasma membrane Biological process carbohydrate transport glucose import transmembrane transport hexose transmembrane transport proton transmembrane transport glucose transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 81031 170441 Ensembl ENSG00000197496 ENSMUSG00000027661 UniProt O95528 Q8VHD6 RefSeq (mRNA) NM_030777 NM_130451 RefSeq (protein) NP_110404 NP_569718 Location (UCSC) Chr 20: 46.71 – 46.74 Mb Chr 2: 165.35 – 165.36 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

SLC2A10 is a member of the facilitative glucose transporter family, which plays a significant role in maintaining glucose homeostasis.[supplied by OMIM]

See also

• Glucose transporter
• Solute carrier family
• Arterial tortuosity syndrome

Further reading

• Dawson PA, Mychaleckyj JC, Fossey SC, et al. (2001). "Sequence and functional analysis of GLUT10: a glucose transporter in the Type 2 diabetes-linked region of chromosome 20q12-13.1". Mol. Genet. Metab. 74 (1–2): 186–99. doi:10.1006/mgme.2001.3212. PMID 11592815.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Richardson S, Neama G, Phillips T, et al. (2003). "Molecular characterization and partial cDNA cloning of facilitative glucose transporters expressed in human articular chondrocytes; stimulation of 2-deoxyglucose uptake by IGF-I and elevated MMP-2 secretion by glucose deprivation". Osteoarthr. Cartil. 11 (2): 92–101. doi:10.1053/joca.2002.0858. PMID 12554125.
• Wood IS, Hunter L, Trayhurn P (2003). "Expression of Class III facilitative glucose transporter genes (GLUT-10 and GLUT-12) in mouse and human adipose tissues". Biochem. Biophys. Res. Commun. 308 (1): 43–9. doi:10.1016/S0006-291X(03)01322-6. PMID 12890477.
• Andersen G, Rose CS, Hamid YH, et al. (2003). "Genetic variation of the GLUT10 glucose transporter (SLC2A10) and relationships to type 2 diabetes and intermediary traits". Diabetes. 52 (9): 2445–8. doi:10.2337/diabetes.52.9.2445. PMID 12941788.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Zaidi SH, Peltekova V, Meyer S, et al. (2005). "A family exhibiting arterial tortuosity syndrome displays homozygosity for markers in the arterial tortuosity locus at chromosome 20q13". Clin. Genet. 67 (2): 183–8. doi:10.1111/j.1399-0004.2004.00391.x. PMID 15679832. S2CID 21973630.
• Mohlke KL, Skol AD, Scott LJ, et al. (2005). "Evaluation of SLC2A10 (GLUT10) as a candidate gene for type 2 diabetes and related traits in Finns". Mol. Genet. Metab. 85 (4): 323–7. doi:10.1016/j.ymgme.2005.04.011. PMID 15936967.
• Segade F, Allred DC, Bowden DW (2005). "Functional characterization of the promoter of the human glucose transporter 10 gene". Biochim. Biophys. Acta. 1730 (2): 147–58. doi:10.1016/j.bbaexp.2005.06.012. PMID 16051383.
• Coucke PJ, Willaert A, Wessels MW, et al. (2006). "Mutations in the facilitative glucose transporter GLUT10 alter angiogenesis and cause arterial tortuosity syndrome" (PDF). Nat. Genet. 38 (4): 452–7. doi:10.1038/ng1764. hdl:11379/29243. PMID 16550171. S2CID 836017.
• Lin WH, Chuang LM, Chen CH, et al. (2006). "Association study of genetic polymorphisms of SLC2A10 gene and type 2 diabetes in the Taiwanese population". Diabetologia. 49 (6): 1214–21. doi:10.1007/s00125-006-0218-3. PMID 16586067.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.