SLC20A1

Sodium-dependent phosphate transporter 1 is a protein that in humans is encoded by the SLC20A1 gene.

SLC20A1
Identifiers
Aliases	SLC20A1, GLVR1, Glvr-1, PIT1, PiT-1, solute carrier family 20 member 1
External IDs	OMIM: 137570; MGI: 108392; HomoloGene: 38049; GeneCards: SLC20A1; OMA:SLC20A1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q14.1 Start 112,645,939 bp End 112,663,825 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2 F1|2 62.79 cM Start 129,040,684 bp End 129,053,536 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon granulocyte cartilage tissue trachea retinal pigment epithelium mucosa of urinary bladder trabecular bone parietal pleura appendix mucosa of paranasal sinus Top expressed in pontine nuclei left colon medial vestibular nucleus facial motor nucleus lobe of cerebellum deep cerebellar nuclei cerebellar vermis fetal liver hematopoietic progenitor cell anterior horn of spinal cord dorsal tegmental nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sodium:phosphate symporter activity high-affinity inorganic phosphate:sodium symporter activity symporter activity signal transducer activity inorganic phosphate transmembrane transporter activity sodium:inorganic phosphate symporter activity Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane Biological process phosphate-containing compound metabolic process positive regulation of I-kappaB kinase/NF-kappaB signaling phosphate ion transmembrane transport phosphate ion transport ion transport sodium ion transmembrane transport sodium ion transport signal transduction transmembrane transport sodium-dependent phosphate transport transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6574 20515 Ensembl ENSG00000144136 ENSMUSG00000027397 UniProt Q8WUM9 Q61609 RefSeq (mRNA) NM_005415 NM_001159593 NM_015747 NM_001355252 RefSeq (protein) NP_005406 NP_001153065 NP_056562 NP_001342181 Location (UCSC) Chr 2: 112.65 – 112.66 Mb Chr 2: 129.04 – 129.05 Mb PubMed search
Wikidata
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Retrovirus receptors allow infection of human and murine cells by various retroviruses. The receptors that have been identified at the molecular level include CD4 (MIM 186940) for human immunodeficiency virus, Rec1 for murine ecotropic virus, and GLVR1 for gibbon ape leukemia virus (see MIM 182090). These 3 proteins show no homology to one another at the DNA or protein level. GLVR1 is a sodium-dependent phosphate symporter.[supplied by OMIM]

Research

It was reported that mutations of the gene may cause epispadias or bladder exstrophy.

See also

• Solute carrier family

Further reading

• Takeuchi Y, Vile RG, Simpson G, et al. (1992). "Feline leukemia virus subgroup B uses the same cell surface receptor as gibbon ape leukemia virus". J. Virol. 66 (2): 1219–22. doi:10.1128/JVI.66.2.1219-1222.1992. PMC 240831. PMID 1309898.
• Johann SV, Gibbons JJ, O'Hara B (1992). "GLVR1, a receptor for gibbon ape leukemia virus, is homologous to a phosphate permease of Neurospora crassa and is expressed at high levels in the brain and thymus". J. Virol. 66 (3): 1635–40. doi:10.1128/JVI.66.3.1635-1640.1992. PMC 240899. PMID 1531369.
• Kaelbling M, Eddy R, Shows TB, et al. (1991). "Localization of the human gene allowing infection by gibbon ape leukemia virus to human chromosome region 2q11-q14 and to the homologous region on mouse chromosome 2". J. Virol. 65 (4): 1743–7. doi:10.1128/JVI.65.4.1743-1747.1991. PMC 239979. PMID 1672162.
• O'Hara B, Johann SV, Klinger HP, et al. (1991). "Characterization of a human gene conferring sensitivity to infection by gibbon ape leukemia virus". Cell Growth Differ. 1 (3): 119–27. PMID 2078500.
• Olah Z, Lehel C, Anderson WB, et al. (1994). "The cellular receptor for gibbon ape leukemia virus is a novel high affinity sodium-dependent phosphate transporter". J. Biol. Chem. 269 (41): 25426–31. doi:10.1016/S0021-9258(18)47267-5. PMID 7929240.
• Miller DG, Miller AD (1994). "A family of retroviruses that utilize related phosphate transporters for cell entry". J. Virol. 68 (12): 8270–6. doi:10.1128/JVI.68.12.8270-8276.1994. PMC 237294. PMID 7966619.
• Johann SV, van Zeijl M, Cekleniak J, O'Hara B (1993). "Definition of a domain of GLVR1 which is necessary for infection by gibbon ape leukemia virus and which is highly polymorphic between species". J. Virol. 67 (11): 6733–6. doi:10.1128/JVI.67.11.6733-6736.1993. PMC 238113. PMID 8411375.
• Tatsumi S, Segawa H, Morita K, et al. (1998). "Molecular cloning and hormonal regulation of PiT-1, a sodium-dependent phosphate cotransporter from rat parathyroid glands". Endocrinology. 139 (4): 1692–9. doi:10.1210/endo.139.4.5925. PMID 9528951.
• Palmer G, Manen D, Bonjour JP, Caverzasio J (1999). "Characterization of the human Glvr-1 phosphate transporter/retrovirus receptor gene and promoter region". Gene. 226 (1): 25–33. doi:10.1016/S0378-1119(98)00572-1. PMID 9889306.
• Jono S, McKee MD, Murry CE, et al. (2000). "Phosphate regulation of vascular smooth muscle cell calcification". Circ. Res. 87 (7): E10–7. doi:10.1161/01.RES.87.7.e10. PMID 11009570.
• Farrell KB, Russ JL, Murthy RK, Eiden MV (2002). "Reassessing the role of region A in Pit1-mediated viral entry". J. Virol. 76 (15): 7683–93. doi:10.1128/JVI.76.15.7683-7693.2002. PMC 136385. PMID 12097582.
• Bottger P, Pedersen L (2003). "Two highly conserved glutamate residues critical for type III sodium-dependent phosphate transport revealed by uncoupling transport function from retroviral receptor function". J. Biol. Chem. 277 (45): 42741–7. doi:10.1074/jbc.M207096200. PMID 12205090.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Cecil DL, Rose DM, Terkeltaub R, Liu-Bryan R (2005). "Role of interleukin-8 in PiT-1 expression and CXCR1-mediated inorganic phosphate uptake in chondrocytes". Arthritis Rheum. 52 (1): 144–54. doi:10.1002/art.20748. PMID 15641067.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
• Li X, Yang HY, Giachelli CM (2006). "Role of the sodium-dependent phosphate cotransporter, Pit-1, in vascular smooth muscle cell calcification". Circ. Res. 98 (7): 905–12. doi:10.1161/01.RES.0000216409.20863.e7. PMID 16527991.
• Bøttger P, Hede SE, Grunnet M, et al. (2007). "Characterization of transport mechanisms and determinants critical for Na+-dependent Pi symport of the PiT family paralogs human PiT1 and PiT2". Am. J. Physiol., Cell Physiol. 291 (6): C1377–87. doi:10.1152/ajpcell.00015.2006. PMID 16790504.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.