SH3BP2 (SH3 domain-binding protein 2) is a protein that comes from a gene located on Chromosome 4. SH3BP2 binds differentially to the SH3 domains of certain proteins of signal transduction pathways. It binds to phosphatidylinositols linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism. It is also associated with cherubism.
| SH3-domain binding protein 2 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | SH3BP2 | ||||||
| NCBI gene | 6452 | ||||||
| HGNC | 10825 | ||||||
| OMIM | 602104 | ||||||
| RefSeq | NM_003023 | ||||||
| UniProt | P78314 | ||||||
| Other data | |||||||
| Locus | Chr. 4 p16.3 | ||||||
| |||||||
See also
editExternal links
edit- GeneReviews/NCBI/NIH/UW entry on Cherubism
- SH3BP2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Genetics Home Reference on SH3BP2
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