SCUBE1

SCUBE1
Identifiers
Aliases	SCUBE1, signal peptide, CUB domain and EGF like domain containing 1
External IDs	OMIM: 611746; MGI: 1890616; HomoloGene: 11224; GeneCards: SCUBE1; OMA:SCUBE1 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	43,343,372 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	83,609,222 bp
RNA expression pattern
	Top expressed in
	gastric mucosa; ; tibia; ; tibial nerve; ; left ovary; ; sural nerve; ; ganglionic eminence; ; right ovary; ; ventricular zone; ; gonad; ; Skeletal muscle tissue of rectus abdominis;
	Top expressed in
	genital tubercle; ; habenula; ; visual cortex; ; superior frontal gyrus; ; primary visual cortex; ; third ventricle; ; urethra; ; female urethra; ; male urethra; ; infundibular recess;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium ion binding; identical protein binding; protein heterodimerization activity;
Cellular component	extracellular region; cell surface; extrinsic component of plasma membrane; membrane; external side of plasma membrane; extracellular space; plasma membrane;
Biological process	endothelial cell differentiation; blood coagulation; inflammatory response; protein homooligomerization; post-embryonic development; adult heart development; signal transduction; cell differentiation; positive regulation of smoothened signaling pathway; extracellular matrix disassembly;
	Sources:Amigo / QuickGO
Orthologs
	80274
	64706
	ENSG00000159307
	ENSMUSG00000016763
	Q8IWY4
	Q6NZL8
	NM_173050
	NM_001271472; NM_001271473; NM_022723
	NP_766638; NP_766638.2
	NP_001258401; NP_001258402; NP_073560
	Wikidata
View/Edit Human	View/Edit Mouse

Signal peptide, CUB domain and EGF like domain containing 1 is a protein that in humans is encoded by the SCUBE1 gene. ^[5]

Function

This gene encodes a cell surface glycoprotein that is a member of the SCUBE (signal peptide, CUB domain, EGF (epidermal growth factor)-like protein) family. Family members have an amino-terminal signal peptide, nine copies of EGF-like repeats and a CUB domain at the carboxyl terminus. This protein is expressed in platelets and endothelial cells and may play an important role in vascular biology.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000159307 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000016763 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Signal peptide, CUB domain and EGF like domain containing 1". Retrieved 2017-05-31.

Yang RB, Ng CK, Wasserman SM, Colman SD, Shenoy S, Mehraban F, Komuves LG, Tomlinson JE, Topper JN (2002). "Identification of a novel family of cell-surface proteins expressed in human vascular endothelium". J. Biol. Chem. 277 (48): 46364–73. doi:10.1074/jbc.M207410200. PMID 12270931.
Budarf ML, Goyette P, Boucher G, Lian J, Graham RR, Claudio JO, Hudson T, Gladman D, Clarke AE, Pope JE, Peschken C, Smith CD, Hanly J, Rich E, Boire G, Barr SG, Zummer M, Fortin PR, Wither J, Rioux JD (2011). "A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles". Genes Immun. 12 (1): 51–8. doi:10.1038/gene.2010.47. PMID 20962850.
Ulusoy S, Ozkan G, Menteşe A, Yavuz A, Karahan SC, Sümer AU (2012). "Signal peptide-CUB-EGF domain-containing protein 1 (SCUBE1) level in hemodialysis patients and parameters affecting that level". Clin. Biochem. 45 (16–17): 1444–9. doi:10.1016/j.clinbiochem.2012.07.103. PMID 22874483.
Orr B, Grace OC, Brown P, Riddick AC, Stewart GD, Franco OE, Hayward SW, Thomson AA (2013). "Reduction of pro-tumorigenic activity of human prostate cancer-associated fibroblasts using Dlk1 or SCUBE1". Dis. Models Mech. 6 (2): 530–6. doi:10.1242/dmm.010355. PMC 3597035. PMID 23136397.
Mentese A, Fidan E, Sumer AU, Karahan SC, Sonmez M, Altay DU, Kavgaci H, Alver A (2012). "Is SCUBE 1 a new biomarker for gastric cancer?". Cancer Biomark. 11 (5): 191–5. doi:10.3233/CBM-2012-00285. PMID 23220851.
Menteşe A, Yilmaz G, Sümer A, Arslan M, Karahan SC, Köksal I (2013). "The diagnostic and prognostic significance of SCUBE1 levels in Crimean-Congo hemorrhagic fever". Int. J. Infect. Dis. 17 (11): e1042–5. doi:10.1016/j.ijid.2013.03.014. PMID 23632301.
Topcu TO, Kavgaci H, Ozdemir F, Aksoy A, Erdem D, Mentese A, Yaman H, Tufan G, Orem A, Aydin F (2015). "Elevated Serum Levels of SCUBE1, a Marker for Coagulation, in Patients with Breast Cancer". Tohoku J. Exp. Med. 237 (2): 127–32. doi:10.1620/tjem.237.127. PMID 26438214.
Liao WJ, Tsao KC, Yang RB (2016). "Electrostatics and N-glycan-mediated membrane tethering of SCUBE1 is critical for promoting bone morphogenetic protein signalling". Biochem. J. 473 (5): 661–72. doi:10.1042/BJ20151041. PMID 26699903. S2CID 20555581.
Chen QH, Lin D, Zhou J, Deng G (2016). "Role of signal peptide-Cub-Egf domain-containing protein-1 in serum as a predictive biomarker of outcome after severe traumatic brain injury". Clin. Chim. Acta. 456: 63–6. doi:10.1016/j.cca.2016.02.021. PMID 26940951.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 22 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000159307 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000016763 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Signal peptide, CUB domain and EGF like domain containing 1". Retrieved 2017-05-31.

[5]

[1]

[2]

[3]

[4]

SCUBE1

Function

References

Further reading