SCFD1

Sec1 family domain-containing protein 1 is a protein that in humans is encoded by the SCFD1 gene.

SCFD1
Identifiers
Aliases	SCFD1, C14orf163, RA410, SLY1, SLY1P, STXBP1L2, sec1 family domain containing 1
External IDs	OMIM: 618207; MGI: 1924233; HomoloGene: 5650; GeneCards: SCFD1; OMA:SCFD1 - orthologs
Gene location (Human) Chr. Chromosome 14 (human) Band 14q12 Start 30,622,291 bp End 30,737,694 bp
Gene location (Mouse) Chr. Chromosome 12 (mouse) Band 12|12 B3 Start 51,424,293 bp End 51,496,884 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon body of pancreas anterior pituitary parotid gland corpus epididymis oral cavity mucosa of paranasal sinus islet of Langerhans biceps brachii bone marrow cells Top expressed in seminal vesicula parotid gland islet of Langerhans calvaria dermis lobe of prostate efferent ductule olfactory epithelium pituitary gland Gonadal ridge More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein N-terminus binding protein binding syntaxin binding protein-containing complex binding Cellular component cytoplasm cytosol Golgi apparatus endoplasmic reticulum membrane membrane cis-Golgi network plasma membrane Golgi transport complex Golgi-associated vesicle Golgi cisterna membrane endoplasmic reticulum Biological process negative regulation of autophagosome assembly regulation of ER to Golgi vesicle-mediated transport response to hypoxia regulation of protein transport retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum toxin transport post-Golgi vesicle-mediated transport vesicle docking involved in exocytosis COPII vesicle coating cell morphogenesis protein transport response to toxic substance vesicle-mediated transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23256 76983 Ensembl ENSG00000092108 ENSMUSG00000020952 UniProt Q8WVM8 Q8BRF7 RefSeq (mRNA) NM_001257376 NM_001283031 NM_001283032 NM_001283033 NM_016106 NM_182835 NM_029825 NM_001306178 RefSeq (protein) NP_001244305 NP_001269960 NP_001269961 NP_001269962 NP_057190 NP_878255 NP_001293107 NP_084101 Location (UCSC) Chr 14: 30.62 – 30.74 Mb Chr 12: 51.42 – 51.5 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Interactions

SCFD1 has been shown to interact with USO1.

Further reading

• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Hirose H, Arasaki K, Dohmae N, Takio K, Hatsuzawa K, Nagahama M, Tani K, Yamamoto A, Tohyama M, Tagaya M (2004). "Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi". EMBO J. 23 (6): 1267–78. doi:10.1038/sj.emboj.7600135. PMC 381410. PMID 15029241.
• Williams AL, Ehm S, Jacobson NC, Xu D, Hay JC (2004). "rsly1 binding to syntaxin 5 is required for endoplasmic reticulum-to-Golgi transport but does not promote SNARE motif accessibility". Mol. Biol. Cell. 15 (1): 162–75. doi:10.1091/mbc.E03-07-0535. PMC 307537. PMID 14565970.
• Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
• Dulubova I, Yamaguchi T, Arac D, Li H, Huryeva I, Min SW, Rizo J, Sudhof TC (2003). "Convergence and divergence in the mechanism of SNARE binding by Sec1/Munc18-like proteins". Proc. Natl. Acad. Sci. U.S.A. 100 (1): 32–7. Bibcode:2003PNAS..100...32D. doi:10.1073/pnas.232701299. PMC 140874. PMID 12506202.
• Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. CiteSeerX 10.1.1.322.2143. doi:10.1093/dnares/5.6.355. PMID 10048485.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Matsuo N, Ogawa S, Takagi T, Wanaka A, Mori T, Matsuyama T, Pinsky DJ, Stern DM, Tohyama M (1997). "Cloning of a putative vesicle transport-related protein, RA410, from cultured rat astrocytes and its expression in ischemic rat brain". J. Biol. Chem. 272 (26): 16438–44. doi:10.1074/jbc.272.26.16438. PMID 9195952.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.