RhoGAP domain

RhoGAP domain is an evolutionary conserved protein domain of GTPase activating proteins towards Rho/Rac/Cdc42-like small GTPases.

RhoGAP domain
Structure of Phospholipase A2.
Identifiers
Symbol	RhoGAP
Pfam	PF00620
InterPro	IPR000198
SMART	RhoGAP
PROSITE	PDOC50238
SCOP2	1rgb / SCOPe / SUPFAM
OPM protein	1xa6
CDD	cd00159
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary PDB 1xa6A:291-444 1f7cA:199-355 1am4B:260-408 1grnB:260-408 1ow3A:260-408 1rgp :260-402 1tx4A:260-408 2ngrB:260-408 1pbwB:129-281

Human proteins containing this domain

ABR; ARHGAP1; ARHGAP10; ARHGAP11A; ARHGAP11B; ARHGAP12; ARHGAP15; ARHGAP17; ARHGAP18; ARHGAP19; ARHGAP20; ARHGAP21; ARHGAP22; ARHGAP23; ARHGAP24; ARHGAP25; ARHGAP26; ARHGAP27; ARHGAP28; ARHGAP29; ARHGAP30; ARHGAP4; ARHGAP5; ARHGAP6; ARHGAP8; ARHGAP9; BCR; BPGAP1; C1; C5orf5; CDGAP; CENTD1; CENTD2; CENTD3; CHN1; CHN2; DEPDC1; DEPDC1A; DEPDC1B; DLC1; FAM13A1; FKSG42; GMIP; GRLF1; HMHA1; INPP5B; KIAA1688; LOC553158; MYO9A; MYO9B; OCRL; OPHN1; PIK3R1; PIK3R2; PRR5; RACGAP1; RACGAP1P; RALBP1; RICH2; RICS; SH3BP1; SLIT1; SNX26; SRGAP1; SRGAP2; SRGAP3; STARD13; STARD8; SYDE1; SYDE2;

References

• Musacchio, A.; Cantley, L. C.; Harrison, S. C. (1996). "Crystal structure of the breakpoint cluster region-homology domain from phosphoinositide 3-kinase p85 alpha subunit". Proceedings of the National Academy of Sciences of the United States of America. 93 (25): 14373–14378. doi:10.1073/pnas.93.25.14373. PMC 26139. PMID 8962058.
• Barrett, T.; Xiao, B.; Dodson, E. J.; Dodson, G.; Ludbrook, S. B.; Nurmahomed, K.; Gamblin, S. J.; Musacchio, A.; Smerdon, S. J.; Eccleston, J. F. (1997). "The structure of the GTPase-activating domain from p50rhoGAP". Nature. 385 (6615): 458–461. doi:10.1038/385458a0. PMID 9009196. S2CID 4235645.
• Gamblin, S. J.; Rittinger, K.; Walker, P. A.; Eccleston, J. F.; Nurmahomed, K.; Owen, D.; Laue, E.; Smerdon, S. J. (1997). "Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP". Nature. 388 (6643): 693–697. doi:10.1038/41805. PMID 9262406. S2CID 4415826.
• Boguski, M. S.; McCormick, F. (1993). "Proteins regulating Ras and its relatives". Nature. 366 (6456): 643–654. doi:10.1038/366643a0. PMID 8259209. S2CID 4338237.