Region 6 or Region VI can refer to:
- One of DVD region
- East Berbice-Corentyne, Region 6 in Guyana
- Region 6, Northwest Territories
- One of health regions of Canada managed by Vitalité Health Network
- Former Region 6 (Johannesburg), an administrative district in the city of Johannesburg, South Africa, from 2000 to 2006
- O'Higgins Region, Chile
- Western Visayas Region, Philippines
- Region 6 War Room