RNASE6

Ribonuclease A family member k6 is a protein that in humans is encoded by the RNASE6 gene.

RNASE6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4X09
Identifiers
Aliases	RNASE6, RAD1, RNS6, RNasek6, ribonuclease A family member k6
External IDs	OMIM: 601981; MGI: 1925666; HomoloGene: 4102; GeneCards: RNASE6; OMA:RNASE6 - orthologs
Gene location (Human) Chr. Chromosome 14 (human) Band 14q11.2 Start 20,781,268 bp End 20,782,467 bp
Gene location (Mouse) Chr. Chromosome 14 (mouse) Band 14|14 C1 Start 51,361,365 bp End 51,369,644 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte spleen blood gallbladder lymph node testicle appendix right coronary artery rectum Top expressed in mesenteric lymph nodes spleen zygote primary oocyte granulocyte embryo secondary oocyte blood embryo bone marrow More reference expression data BioGPS n/a
Gene ontology Molecular function nuclease activity endonuclease activity hydrolase activity nucleic acid binding ribonuclease activity Cellular component extracellular region extracellular space intracellular anatomical structure cytoplasmic vesicle lysosome Biological process defense response RNA catabolic process antimicrobial humoral response antibacterial humoral response innate immune response defense response to virus antimicrobial humoral immune response mediated by antimicrobial peptide RNA phosphodiester bond hydrolysis defense response to bacterium nucleic acid phosphodiester bond hydrolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6039 78416 Ensembl ENSG00000169413 ENSMUSG00000021880 UniProt Q93091 Q6IB39 Q9D244 RefSeq (mRNA) NM_005615 NM_030098 NM_001360117 RefSeq (protein) NP_005606 NP_005606.1 NP_084374 NP_001347046 Location (UCSC) Chr 14: 20.78 – 20.78 Mb Chr 14: 51.36 – 51.37 Mb PubMed search
Wikidata
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Function

The protein encoded by this gene is a member of the ribonuclease A superfamily and functions in the urinary tract. The protein has broad-spectrum antimicrobial activity against pathogenic bacteria. [provided by RefSeq, Nov 2014].

Further reading

• Becknell B, Eichler TE, Beceiro S, Li B, Easterling RS, Carpenter AR, James CL, McHugh KM, Hains DS, Partida-Sanchez S, Spencer JD (January 2015). "Ribonucleases 6 and 7 have antimicrobial function in the human and murine urinary tract". Kidney Int. 87 (1): 151–61. doi:10.1038/ki.2014.268. PMC 4281292. PMID 25075772.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.