RAB5B

Ras-related protein Rab-5B is a protein that in humans is encoded by the RAB5B gene.

RAB5B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2HEI
Identifiers
Aliases	RAB5B, Rab-5B, member RAS oncogene family
External IDs	OMIM: 179514; MGI: 105938; HomoloGene: 104027; GeneCards: RAB5B; OMA:RAB5B - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12q13.2 Start 55,973,913 bp End 55,996,683 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10|10 D3 Start 128,513,044 bp End 128,532,133 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in C1 segment epithelium of colon skin of leg ectocervix popliteal artery tibial arteries skin of abdomen muscle layer of sigmoid colon gastric mucosa right coronary artery Top expressed in granulocyte dentate gyrus of hippocampal formation granule cell muscle of thigh lip primary visual cortex superior frontal gyrus esophagus neural layer of retina genital tubercle ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GDP binding GTP binding GTP-dependent protein binding protein binding GTPase activity Cellular component endosome membrane melanosome endocytic vesicle intracellular anatomical structure early endosome extracellular exosome plasma membrane secretory granule membrane early endosome membrane intracellular membrane-bounded organelle anchored component of synaptic vesicle membrane Biological process regulation of endocytosis antigen processing and presentation endosome organization plasma membrane to endosome transport protein transport neutrophil degranulation transport intracellular protein transport Rab protein signal transduction endocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5869 19344 Ensembl ENSG00000111540 ENSMUSG00000000711 UniProt P61020 P61021 RefSeq (mRNA) NM_001252036 NM_001252037 NM_002868 NM_011229 NM_177411 RefSeq (protein) NP_001238965 NP_001238966 NP_002859 NP_803130 Location (UCSC) Chr 12: 55.97 – 56 Mb Chr 10: 128.51 – 128.53 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Bucci C, Lütcke A, Steele-Mortimer O, Olkkonen VM, Dupree P, Chiariello M, Bruni CB, Simons K, Zerial M (1995). "Co-operative regulation of endocytosis by three Rab5 isoforms". FEBS Lett. 366 (1): 65–71. doi:10.1016/0014-5793(95)00477-Q. PMID 7789520. S2CID 40284549.
• Korenberg JR, Chen XN, Adams MD, Venter JC (1996). "Toward a cDNA map of the human genome". Genomics. 29 (2): 364–70. doi:10.1006/geno.1995.9993. PMID 8666383.
• Bao S, Zhu J, Garvey WT (1999). "Cloning of Rab GTPases expressed in human skeletal muscle: studies in insulin-resistant subjects". Horm. Metab. Res. 30 (11): 656–62. doi:10.1055/s-2007-978953. PMID 9918381. S2CID 23540699.
• Callaghan J, Nixon S, Bucci C, Toh BH, Stenmark H (1999). "Direct interaction of EEA1 with Rab5b". Eur. J. Biochem. 265 (1): 361–6. doi:10.1046/j.1432-1327.1999.00743.x. PMID 10491193.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Tall GG, Barbieri MA, Stahl PD, Horazdovsky BF (2001). "Ras-activated endocytosis is mediated by the Rab5 guanine nucleotide exchange activity of RIN1". Dev. Cell. 1 (1): 73–82. doi:10.1016/S1534-5807(01)00008-9. PMID 11703925.
• Saito K, Murai J, Kajiho H, Kontani K, Kurosu H, Katada T (2002). "A novel binding protein composed of homophilic tetramer exhibits unique properties for the small GTPase Rab5". J. Biol. Chem. 277 (5): 3412–8. doi:10.1074/jbc.M106276200. PMID 11733506.
• Merithew E, Stone C, Eathiraj S, Lambright DG (2003). "Determinants of Rab5 interaction with the N terminus of early endosome antigen 1". J. Biol. Chem. 278 (10): 8494–500. doi:10.1074/jbc.M211514200. PMID 12493736.
• Kajiho H, Saito K, Tsujita K, Kontani K, Araki Y, Kurosu H, Katada T (2004). "RIN3: a novel Rab5 GEF interacting with amphiphysin II involved in the early endocytic pathway". J. Cell Sci. 116 (Pt 20): 4159–68. doi:10.1242/jcs.00718. PMID 12972505.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Chi A, Valencia JC, Hu ZZ, Watabe H, Yamaguchi H, Mangini NJ, Huang H, Canfield VA, Cheng KC, Yang F, Abe R, Yamagishi S, Shabanowitz J, Hearing VJ, Wu C, Appella E, Hunt DF (2007). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes". J. Proteome Res. 5 (11): 3135–44. doi:10.1021/pr060363j. PMID 17081065.
• Hirota Y, Kuronita T, Fujita H, Tanaka Y (2007). "A role for Rab5 activity in the biogenesis of endosomal and lysosomal compartments". Biochem. Biophys. Res. Commun. 364 (1): 40–7. doi:10.1016/j.bbrc.2007.09.089. PMID 17927960.