Pyridoxine 4-dehydrogenase

In enzymology, a pyridoxine 4-dehydrogenase (EC 1.1.1.65) is an enzyme that catalyzes the chemical reaction

pyridoxine 4-dehydrogenase
Identifiers
EC no.1.1.1.65
CAS no.9028-64-2
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins
pyridoxine + NADP+ pyridoxal + NADPH + H+

Thus, the two substrates of this enzyme are pyridoxine and NADP+, whereas its 3 products are pyridoxal, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donors with NAD+ or NADP+ as acceptors. The systematic name of this enzyme class is pyridoxine:NADP+ 4-oxidoreductase. Other names in common use include pyridoxin dehydrogenase, pyridoxol dehydrogenase, and pyridoxine dehydrogenase. This enzyme participates in vitamin B6 metabolism.

References

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  • Holzer H, Schneider S (1961). "[Purification and characterization of a TPN-dependent pyridoxol dehydrogenase from brewers yeast.]". Biochim. Biophys. Acta (in German). 48: 71–6. doi:10.1016/0006-3002(61)90516-9. PMID 13715611.