Pyeazolam

Pyeazolam
Identifiers
	IUPAC name 8-ethynyl-1-methyl-6-(pyridin-2-yl)-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine;
CAS Number	1349115-59-8;
PubChem CID	71811108;
ChemSpider	30768095;
Chemical and physical data
Formula	C18H13N5
Molar mass	299.337 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC1=NN=C2N1C3=C(C=C(C=C3)C#C)C(=NC2)C4=CC=CC=N4;
	InChI InChI=1S/C18H13N5/c1-3-13-7-8-16-14(10-13)18(15-6-4-5-9-19-15)20-11-17-22-21-12(2)23(16)17/h1,4-10H,11H2,2H3; Key:LQKOTGTWBANJBS-UHFFFAOYSA-N;

Pyeazolam (SH-TRI-108) is a triazolobenzodiazepine derivative which has been sold online as a designer drug. It has been found to be relatively selective for the α₅ subtype of GABA_A receptors, in a similar manner to the related compound QH-ii-066,^[1] and is claimed to have an effects profile more similar to alcohol than typical benzodiazepines.

Several possible routes for synthesis have been determined.^[2]

References

^ Clayton T, Poe MM, Rallapalli S, Biawat P, Savić MM, Rowlett JK, et al. (2015). "A Review of the Updated Pharmacophore for the Alpha 5 GABA(A) Benzodiazepine Receptor Model". International Journal of Medicinal Chemistry. 2015: 430248. doi:10.1155/2015/430248. PMC 4657098. PMID 26682068.
^ https://www.benchchem.com/product/b1430148

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[1] Clayton T, Poe MM, Rallapalli S, Biawat P, Savić MM, Rowlett JK, et al. (2015). "A Review of the Updated Pharmacophore for the Alpha 5 GABA(A) Benzodiazepine Receptor Model". International Journal of Medicinal Chemistry. 2015: 430248. doi:10.1155/2015/430248. PMC 4657098. PMID 26682068.

[2] ttps://www.benchchem.com/product/b1430148

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Identifiers

IUPAC name 8-ethynyl-1-methyl-6-(pyridin-2-yl)-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine
CAS Number	1349115-59-8
PubChem CID	71811108
ChemSpider	30768095
Chemical and physical data
Formula	C₁₈H₁₃N₅
Molar mass	299.337 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CC1=NN=C2N1C3=C(C=C(C=C3)C#C)C(=NC2)C4=CC=CC=N4
InChI InChI=1S/C18H13N5/c1-3-13-7-8-16-14(10-13)18(15-6-4-5-9-19-15)20-11-17-22-21-12(2)23(16)17/h1,4-10H,11H2,2H3 Key:LQKOTGTWBANJBS-UHFFFAOYSA-N

Pyeazolam

See also

References