The Poxvirus AX element late mRNA family represents a cis-regulatory element present at the 3' end of poxvirus late ATI mRNA and is known as the AX element. The AX element is involved in directing the efficient production and orientation-dependent formation of late RNAs.[1] It is likely that this element directs the endonucleolytic cleavage of the transcript. It has been shown that the F17R late mRNA transcript which is also cleaved is also likely to share a common factor in their mechanism despite a lack of any obvious similarity in its cis-regulatory RNA element.[2]
| Poxvirus AX element late mRNA cis-regulatory element | |
|---|---|
 Predicted secondary structure and sequence conservation of Pox_AX_element | |
| Identifiers | |
| Symbol | Pox_AX_element |
| Rfam | RF00384 |
| Other data | |
| RNA type | Cis-reg |
| Domain(s) | Viruses |
| SO | SO:0000233 |
| PDB structures | PDBe |
See also
editReferences
edit- ^ Howard, ST; Ray CA; Patel DD; Antczak JB; Pickup DJ (1999). "A 43-nucleotide RNA cis-acting element governs the site-specific formation of the 3' end of a poxvirus late mRNA". Virology. 255 (1): 190–204. doi:10.1006/viro.1998.9547. PMID 10049834.
- ^ D'Costa SM, Antczak JB, Pickup DJ, Condit RC (February 2004). "Post-transcription cleavage generates the 3' end of F17R transcripts in vaccinia virus". Virology. 319 (1): 1–11. doi:10.1016/j.virol.2003.09.041. PMID 14967483.
External links
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