Popek is a Polish surname. Notable people with the surname include:
- Edward Popek (1919-2001), American flying ace
- Gerald J. Popek (1946-2008), American computer scientist
- Jacek Popek (born 1978), Polish football player
- Mark Popek (born 1990), American football player
- Tadeusz Popek (1915-1942), World War II Polish resistance member