Plakophilin-4 is a protein that in humans is encoded by the PKP4 gene.[5][6][7]

PKP4
Identifiers
AliasesPKP4, p0071, plakophilin 4
External IDsOMIM: 604276; MGI: 109281; HomoloGene: 2689; GeneCards: PKP4; OMA:PKP4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)Chr 2: 158.46 – 158.68 MbChr 2: 59.16 – 59.36 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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Armadillo-like proteins are characterized by a series of armadillo repeats, first defined in the Drosophila 'armadillo' gene product, that are typically 42 to 45 amino acids in length. These proteins can be divided into subfamilies based on their number of repeats, their overall sequence similarity, and the dispersion of the repeats throughout their sequences. Members of the p120(ctn)/plakophilin subfamily of Armadillo-like proteins, including CTNND1, CTNND2, PKP1, PKP2, PKP4, and ARVCF. PKP4 may be a component of desmosomal plaque and other adhesion plaques and is thought to be involved in regulating junctional plaque organization and cadherin function. Multiple transcript variants have been found for this gene, but the full-length nature of only two of them have been described so far. These two variants encode distinct isoforms.[7]

Interactions

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PKP4 has been shown to interact with:

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000144283Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026991Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Paffenholz R, Franke WW (December 1997). "Identification and localization of a neurally expressed member of the plakoglobin/armadillo multigene family". Differentiation. 61 (5): 293–304. doi:10.1046/j.1432-0436.1997.6150293.x. PMID 9342840.
  6. ^ Hatzfeld M, Nachtsheim C (May 1997). "Cloning and characterization of a new armadillo family member, p0071, associated with the junctional plaque: evidence for a subfamily of closely related proteins". J Cell Sci. 109 (11): 2767–78. doi:10.1242/jcs.109.11.2767. PMID 8937994.
  7. ^ a b "Entrez Gene: PKP4 plakophilin 4".
  8. ^ Izawa I, Nishizawa M, Tomono Y, Ohtakara K, Takahashi T, Inagaki M (May 2002). "ERBIN associates with p0071, an armadillo protein, at cell-cell junctions of epithelial cells". Genes Cells. 7 (5): 475–85. doi:10.1046/j.1365-2443.2002.00533.x. PMID 12047349. S2CID 12598418.
  9. ^ Jaulin-Bastard F, Arsanto JP, Le Bivic A, Navarro C, Vély F, Saito H, Marchetto S, Hatzfeld M, Santoni MJ, Birnbaum D, Borg JP (January 2002). "Interaction between Erbin and a Catenin-related protein in epithelial cells". J. Biol. Chem. 277 (4): 2869–75. doi:10.1074/jbc.M109652200. PMID 11711544.
  10. ^ Laura RP, Witt AS, Held HA, Gerstner R, Deshayes K, Koehler MF, Kosik KS, Sidhu SS, Lasky LA (April 2002). "The Erbin PDZ domain binds with high affinity and specificity to the carboxyl termini of delta-catenin and ARVCF". J. Biol. Chem. 277 (15): 12906–14. doi:10.1074/jbc.M200818200. PMID 11821434.
  11. ^ Deguchi M, Iizuka T, Hata Y, Nishimura W, Hirao K, Yao I, Kawabe H, Takai Y (September 2000). "PAPIN. A novel multiple PSD-95/Dlg-A/ZO-1 protein interacting with neural plakophilin-related armadillo repeat protein/delta-catenin and p0071". J. Biol. Chem. 275 (38): 29875–80. doi:10.1074/jbc.M005384200. PMID 10896674.
  12. ^ Ohno H, Hirabayashi S, Iizuka T, Ohnishi H, Fujita T, Hata Y (October 2002). "Localization of p0071-interacting proteins, plakophilin-related armadillo-repeat protein-interacting protein (PAPIN) and ERBIN, in epithelial cells". Oncogene. 21 (46): 7042–9. doi:10.1038/sj.onc.1205852. PMID 12370826.
  13. ^ Stahl B, Diehlmann A, Südhof TC (April 1999). "Direct interaction of Alzheimer's disease-related presenilin 1 with armadillo protein p0071". J. Biol. Chem. 274 (14): 9141–8. doi:10.1074/jbc.274.14.9141. PMID 10092585.

Further reading

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