In enzymology, a phosphoribokinase (EC 2.7.1.18) is an enzyme that catalyzes the chemical reaction

phosphoribokinase
Identifiers
EC no.2.7.1.18
CAS no.9030-59-5
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ATP + D-ribose 5-phosphate ADP + D-ribose 1,5-bisphosphate

Thus, the two substrates of this enzyme are ATP and D-ribose 5-phosphate, whereas its two products are ADP and D-ribose 1,5-bisphosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:D-ribose-5-phosphate 1-phosphotransferase. This enzyme is also called phosphoribokinase (phosphorylating).

References

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  • Krebs EG (1966). Phosphorylase b kinase from rabbit muscle. Methods in Enzymology. Vol. 8. pp. 543–546. doi:10.1016/0076-6879(66)08097-2. ISBN 978-0-12-181808-1.
  • Kalckar HM (1953). "The role of phosphoglycosyl compounds in the biosynthesis of nucleosides and nucleotides". Biochimica et Biophysica Acta. 12 (1–2): 250–64. doi:10.1016/0006-3002(53)90144-9. PMID 13115434.