Patchoulol synthase

Patchoulol synthase (EC 4.2.3.70) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase (patchoulol-forming).^[1]^[2]^[3] This enzyme catalyses the following chemical reaction

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References

^ Croteau R, Munck SL, Akoh CC, Fisk HJ, Satterwhite DM (July 1987). "Biosynthesis of the sesquiterpene patchoulol from farnesyl pyrophosphate in leaf extracts of Pogostemon cablin (patchouli): mechanistic considerations". Archives of Biochemistry and Biophysics. 256 (1): 56–68. doi:10.1016/0003-9861(87)90425-5. PMID 3038029.
^ Munck SL, Croteau R (October 1990). "Purification and characterization of the sesquiterpene cyclase patchoulol synthase from Pogostemon cablin". Archives of Biochemistry and Biophysics. 282 (1): 58–64. doi:10.1016/0003-9861(90)90086-e. PMID 2171435.
^ Faraldos JA, Wu S, Chappell J, Coates RM (March 2010). "Doubly deuterium-labeled patchouli alcohol from cyclization of singly labeled [2-²H₁]farnesyl diphosphate catalyzed by recombinant patchoulol synthase". Journal of the American Chemical Society. 132 (9): 2998–3008. doi:10.1021/ja909251r. PMID 20148554.

Patchoulol+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)