PURB

Transcriptional activator protein Pur-beta is a protein that in humans is encoded by the PURB gene.

PURB
Identifiers
Aliases	PURB, PURBETA, purine-rich element binding protein B, purine rich element binding protein B
External IDs	OMIM: 608887; MGI: 1338779; HomoloGene: 69087; GeneCards: PURB; OMA:PURB - orthologs
Gene location (Human) Chr. Chromosome 7 (human) Band 7p13 Start 44,876,299 bp End 44,885,530 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11 A1|11 4.16 cM Start 6,417,599 bp End 6,425,917 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of arm cerebellar vermis pancreatic epithelial cell gingival epithelium pancreatic ductal cell visceral pleura Brodmann area 23 tibialis anterior muscle epithelium of nasopharynx myocardium of left ventricle Top expressed in lateral septal nucleus anterior amygdaloid area Region I of hippocampus proper primary motor cortex piriform cortex olfactory tubercle cingulate gyrus superior colliculus lateral geniculate nucleus subiculum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA binding double-stranded DNA binding SMAD binding single-stranded DNA binding transcription factor binding mRNA binding RNA binding DNA-binding transcription factor activity, RNA polymerase II-specific purine-rich negative regulatory element binding sequence-specific DNA binding Cellular component DNA replication factor A complex nucleus Biological process regulation of myeloid cell differentiation regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II cell population proliferation cell differentiation transcription, DNA-templated negative regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5814 19291 Ensembl ENSG00000146676 ENSMUSG00000094483 UniProt Q96QR8 O35295 RefSeq (mRNA) NM_033224 NM_011221 RefSeq (protein) NP_150093 NP_035351 Location (UCSC) Chr 7: 44.88 – 44.89 Mb Chr 11: 6.42 – 6.43 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans.

Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia.

Further reading

• Sanger Centre T, Washington University Genome Sequencing Cente T (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
• Kelm RJ, Cogan JG, Elder PK, Strauch AR, Getz MJ (1999). "Molecular interactions between single-stranded DNA-binding proteins associated with an essential MCAT element in the mouse smooth muscle alpha-actin promoter". J. Biol. Chem. 274 (20): 14238–45. doi:10.1074/jbc.274.20.14238. PMID 10318844.
• Lezon-Geyda K, Najfeld V, Johnson EM (2001). "Deletions of PURA, at 5q31, and PURB, at 7p13, in myelodysplastic syndrome and progression to acute myelogenous leukemia". Leukemia. 15 (6): 954–62. doi:10.1038/sj.leu.2402108. PMID 11417483. S2CID 7186291.
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherer SW, Cheung J, MacDonald JR, Osborne LR, Nakabayashi K, Herbrick JA, Carson AR, Parker-Katiraee L, Skaug J (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Hillier LW, Fulton RS, Fulton LA, Graves TA, Pepin KH, Wagner-Mcpherson C, Layman D, Maas J, Jaeger S (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
• Gupta M, Sueblinvong V, Raman J, Jeevanandam V, Gupta MP (2004). "Single-stranded DNA-binding proteins PURalpha and PURbeta bind to a purine-rich negative regulatory element of the alpha-myosin heavy chain gene and control transcriptional and translational regulation of the gene expression. Implications in the repression of alpha-myosin heavy chain during heart failure". J. Biol. Chem. 278 (45): 44935–48. doi:10.1074/jbc.M307696200. PMID 12933792.
• Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.