PTPLAD1

Protein tyrosine phosphatase-like protein PTPLAD1 is an enzyme that in humans is encoded by the PTPLAD1 gene.

HACD3
Identifiers
Aliases	HACD3, B-IND1, BIND1, HSPC121, PTPLAD1, 3-hydroxyacyl-CoA dehydratase 3
External IDs	OMIM: 615940; MGI: 1889341; HomoloGene: 9494; GeneCards: HACD3; OMA:HACD3 - orthologs
Gene location (Human) Chr. Chromosome 15 (human) Band 15q22.31 Start 65,530,418 bp End 65,578,349 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 C Start 64,894,265 bp End 64,928,975 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pons pars compacta retinal pigment epithelium renal medulla superior vestibular nucleus pars reticulata lateral nuclear group of thalamus ventral tegmental area middle temporal gyrus inferior ganglion of vagus nerve Top expressed in Paneth cell substantia nigra facial motor nucleus pineal gland motor neuron fossa condyle vestibular sensory epithelium suprachiasmatic nucleus pituitary gland More reference expression data BioGPS n/a
Gene ontology Molecular function GTPase activator activity protein binding lyase activity enzyme binding 3-hydroxyacyl-CoA dehydratase activity 3-hydroxy-lignoceroyl-CoA dehydratase activity 3-hydroxy-behenoyl-CoA dehydratase activity 3-hydroxy-arachidoyl-CoA dehydratase activity very-long-chain 3-hydroxyacyl-CoA dehydratase activity Cellular component integral component of membrane nuclear membrane endoplasmic reticulum membrane membrane focal adhesion endoplasmic reticulum mitochondrion cytosol integral component of endoplasmic reticulum membrane Biological process positive regulation by virus of viral protein levels in host cell lipid metabolism small GTPase mediated signal transduction fatty acid metabolic process JNK cascade fatty acid biosynthetic process very long-chain fatty acid biosynthetic process Rho protein signal transduction fatty acid elongation positive regulation of viral genome replication Rac protein signal transduction I-kappaB kinase/NF-kappaB signaling positive regulation of GTPase activity sphingolipid biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51495 57874 Ensembl ENSG00000074696 ENSMUSG00000033629 UniProt Q9P035 Q8K2C9 RefSeq (mRNA) NM_016395 NM_021345 RefSeq (protein) NP_057479 NP_067320 Location (UCSC) Chr 15: 65.53 – 65.58 Mb Chr 9: 64.89 – 64.93 Mb PubMed search
Wikidata
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Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Sabbah M, Saucier C, Redeuilh G (2006). "Human B-ind1 gene promoter: cloning and regulation by histone deacetylase inhibitors". Gene. 374: 128–33. doi:10.1016/j.gene.2006.01.022. PMID 16516406.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.