PPP3R2

Calcineurin subunit B type 2 is a protein that in humans is encoded by the PPP3R2 gene. Among its related pathways are MAPK signaling pathway and GPCR pathway. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CHP1.

PPP3R2
Identifiers
Aliases	PPP3R2, PPP3RL, protein phosphatase 3 regulatory subunit B, beta
External IDs	OMIM: 613821; MGI: 107171; HomoloGene: 133815; GeneCards: PPP3R2; OMA:PPP3R2 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) Band 9q31.1 Start 101,591,604 bp End 101,595,021 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 B1 Start 49,678,747 bp End 49,682,024 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm left testis right testis testicle muscular system muscle skeletal muscle lower limb muscles right coronary artery muscle of leg Top expressed in seminiferous tubule spermatocyte spermatid embryo pancreas islet of Langerhans hypothalamus cerebral cortex nucleus of brain hippocampus proper More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 5535 19059 Ensembl ENSG00000188386 ENSMUSG00000028310 UniProt Q96LZ3 Q63811 RefSeq (mRNA) NM_147180 NM_001004025 RefSeq (protein) NP_671709 NP_001004025 Location (UCSC) Chr 9: 101.59 – 101.6 Mb Chr 4: 49.68 – 49.68 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Mukai H, Chang CD, Tanaka H, et al. (1991). "cDNA cloning of a novel testis-specific calcineurin B-like protein". Biochem. Biophys. Res. Commun. 179 (3): 1325–30. doi:10.1016/0006-291X(91)91718-R. PMID 1718268.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Bennasser Y, Badou A, Tkaczuk J, Bahraoui E (2003). "Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha". Virology. 303 (1): 174–80. doi:10.1006/viro.2002.1676. PMID 12482669.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Koefoed-Nielsen PB, Karamperis N, Højskov C, et al. (2007). "The calcineurin activity profiles of cyclosporin and tacrolimus are different in stable renal transplant patients". Transpl. Int. 19 (10): 821–7. doi:10.1111/j.1432-2277.2006.00359.x. PMID 16961774. S2CID 1891740.
• Saeki M, Irie Y, Ni L, et al. (2007). "Calcineurin potentiates the activation of procaspase-3 by accelerating its proteolytic maturation". J. Biol. Chem. 282 (16): 11786–94. doi:10.1074/jbc.M609347200. PMID 17324936.
• Jang H, Cho EJ, Youn HD (2007). "A new calcineurin inhibition domain in Cabin1". Biochem. Biophys. Res. Commun. 359 (1): 129–35. doi:10.1016/j.bbrc.2007.05.066. PMID 17531200.