POLR3G

Polymerase (RNA) III (DNA directed) polypeptide G (32kD) is a protein that in humans is encoded by the POLR3G gene.

POLR3G
Identifiers
Aliases	POLR3G, RPC32, RPC7, polymerase (RNA) III subunit G, RNA polymerase III subunit G, C31
External IDs	OMIM: 617456; MGI: 1914736; HomoloGene: 38184; GeneCards: POLR3G; OMA:POLR3G - orthologs
Gene location (Human) Chr. Chromosome 5 (human) Band 5q14.3 Start 90,471,748 bp End 90,514,557 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13|13 C3 Start 81,821,962 bp End 81,859,132 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in spinal ganglia sural nerve testicle tendon of biceps brachii secondary oocyte gonad internal globus pallidus monocyte trigeminal ganglion buccal mucosa cell Top expressed in lumbar spinal ganglion morula primitive streak epiblast esophagus facial motor nucleus yolk sac embryo embryo genital tubercle More reference expression data BioGPS n/a
Gene ontology Molecular function DNA-directed 5'-3' RNA polymerase activity protein binding Cellular component RNA polymerase III complex cytosol nucleoplasm nucleus cytoplasm Biological process positive regulation of interferon-beta production immune system process cell population proliferation defense response to virus positive regulation of innate immune response innate immune response regulation of transcription by RNA polymerase III transcription by RNA polymerase III positive regulation of type I interferon production Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10622 67486 Ensembl ENSG00000113356 ENSMUSG00000035834 UniProt O15318 Q6NXY9 RefSeq (mRNA) NM_006467 NM_001370351 NM_001370352 NM_001370353 NM_001370354 NM_001081176 NM_026190 RefSeq (protein) NP_006458 NP_001357280 NP_001357281 NP_001357282 NP_001357283 NP_001074645 Location (UCSC) Chr 5: 90.47 – 90.51 Mb Chr 13: 81.82 – 81.86 Mb PubMed search
Wikidata
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Further reading

• Ablasser A, Bauernfeind F, Hartmann G, Latz E, Fitzgerald KA, Hornung V (October 2009). "RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate". Nature Immunology. 10 (10): 1065–1072. doi:10.1038/ni.1779. PMC 3878616. PMID 19609254.
• Chiu YH, Macmillan JB, Chen ZJ (August 2009). "RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway". Cell. 138 (3): 576–591. doi:10.1016/j.cell.2009.06.015. PMC 2747301. PMID 19631370.
• Chantarangsu S, Mushiroda T, Mahasirimongkol S, Kiertiburanakul S, Sungkanuparph S, Manosuthi W, et al. (August 2011). "Genome-wide association study identifies variations in 6p21.3 associated with nevirapine-induced rash". Clinical Infectious Diseases. 53 (4): 341–348. doi:10.1093/cid/cir403. PMID 21810746.
• Wong RC, Pollan S, Fong H, Ibrahim A, Smith EL, Ho M, et al. (October 2011). "A novel role for an RNA polymerase III subunit POLR3G in regulating pluripotency in human embryonic stem cells". Stem Cells. 29 (10): 1517–1527. doi:10.1002/stem.714. PMID 21898682. S2CID 24305950.
• Jang KL, Collins MK, Latchman DS (1992). "The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC". Journal of Acquired Immune Deficiency Syndromes. 5 (11): 1142–1147. PMID 1403646.
• Wang Z, Roeder RG (May 1997). "Three human RNA polymerase III-specific subunits form a subcomplex with a selective function in specific transcription initiation". Genes & Development. 11 (10): 1315–1326. doi:10.1101/gad.11.10.1315. PMID 9171375.
• Hu P, Wu S, Sun Y, Yuan CC, Kobayashi R, Myers MP, Hernandez N (November 2002). "Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits". Molecular and Cellular Biology. 22 (22): 8044–8055. doi:10.1128/MCB.22.22.8044-8055.2002. PMC 134740. PMID 12391170.