POLR3F

DNA-directed RNA polymerase III subunit RPC6 is an enzyme that in humans is encoded by the POLR3F gene.

POLR3F
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DK5, 2YU3
Identifiers
Aliases	POLR3F, RPC39, RPC6, polymerase (RNA) III subunit F, RNA polymerase III subunit F, C34
External IDs	OMIM: 617455; MGI: 1924086; HomoloGene: 4722; GeneCards: POLR3F; OMA:POLR3F - orthologs
Gene location (Human) Chr. Chromosome 20 (human) Band 20p11.23 Start 18,467,389 bp End 18,484,646 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 G1 Start 144,369,638 bp End 144,383,915 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar hemisphere right hemisphere of cerebellum gonad Achilles tendon testicle Brodmann area 9 ganglionic eminence right frontal lobe ventricular zone monocyte Top expressed in saccule ectoderm otic vesicle otic placode Rostral migratory stream human fetus zygote tail of embryo genital tubercle secondary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-directed 5'-3' RNA polymerase activity protein binding RNA polymerase III activity double-stranded DNA binding DNA binding Cellular component RNA polymerase III complex cytosol nucleus nucleoplasm Biological process positive regulation of interferon-beta production immune system process defense response to virus positive regulation of innate immune response transcription by RNA polymerase III innate immune response regulation of transcription by RNA polymerase III positive regulation of type I interferon production Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10621 70408 Ensembl ENSG00000132664 ENSMUSG00000027427 UniProt Q9H1D9 Q921X6 RefSeq (mRNA) NM_001282526 NM_006466 NM_029763 NM_027417 RefSeq (protein) NP_001269455 NP_006457 NP_084039 Location (UCSC) Chr 20: 18.47 – 18.48 Mb Chr 2: 144.37 – 144.38 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is one of more than a dozen subunits forming eukaryotic RNA polymerase III (RNA Pol III), which transcribes 5S ribosomal RNA and tRNA genes. This protein has been shown to bind both TFIIIB90 and TBP, two subunits of RNA polymerase III transcription initiation factor IIIB (TFIIIB). Unlike most of the other RNA Pol III subunits, the encoded protein is unique to this polymerase.

Further reading

• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070.
• Hu P, Wu S, Sun Y, Yuan CC, Kobayashi R, Myers MP, Hernandez N (Nov 2002). "Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits" (PDF). Molecular and Cellular Biology. 22 (22): 8044–55. doi:10.1128/MCB.22.22.8044-8055.2002. PMC 134740. PMID 12391170.
• Jones E, Kimura H, Vigneron M, Wang Z, Roeder RG, Cook PR (Jan 2000). "Isolation and characterization of monoclonal antibodies directed against subunits of human RNA polymerases I, II, and III". Experimental Cell Research. 254 (1): 163–72. doi:10.1006/excr.1999.4739. PMID 10623476.
• Hsieh YJ, Kundu TK, Wang Z, Kovelman R, Roeder RG (Nov 1999). "The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity". Molecular and Cellular Biology. 19 (11): 7697–704. doi:10.1128/mcb.19.11.7697. PMC 84812. PMID 10523658.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Jang KL, Collins MK, Latchman DS (1992). "The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC". Journal of Acquired Immune Deficiency Syndromes. 5 (11): 1142–7. PMID 1403646.