POLR3C

DNA-directed RNA polymerase III subunit RPC3 is an enzyme that in humans is encoded by the POLR3C gene.

POLR3C
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2XUB, 2XV4, 5AFQ
Identifiers
Aliases	POLR3C, RPC3, RPC62, polymerase (RNA) III subunit C, RNA polymerase III subunit C, C82
External IDs	OMIM: 617454; MGI: 1921664; HomoloGene: 38185; GeneCards: POLR3C; OMA:POLR3C - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1q21.1 Start 145,824,088 bp End 145,844,402 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3|3 F2.1 Start 96,618,806 bp End 96,634,944 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad Achilles tendon stromal cell of endometrium monocyte left testis right testis canal of the cervix granulocyte gallbladder right ovary Top expressed in otic vesicle intestinal villus yolk sac mesenteric lymph nodes granulocyte epiblast seminiferous tubule ventricular zone jejunum ileum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-directed 5'-3' RNA polymerase activity DNA binding protein binding RNA polymerase III activity single-stranded DNA binding Cellular component RNA polymerase III complex cytosol nucleoplasm nucleus Biological process positive regulation of interferon-beta production regulation of transcription by RNA polymerase III defense response to virus transcription, DNA-templated positive regulation of innate immune response immune system process innate immune response transcription by RNA polymerase III positive regulation of type I interferon production Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10623 74414 Ensembl ENSG00000186141 ENSMUSG00000028099 UniProt Q9BUI4 Q9D483 RefSeq (mRNA) NM_001303456 NM_006468 NM_028925 RefSeq (protein) NP_001290385 NP_006459 NP_083201 Location (UCSC) Chr 1: 145.82 – 145.84 Mb Chr 3: 96.62 – 96.63 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Interactions

POLR3C has been shown to interact with GTF3C4.

Related gene problems

• TAR syndrome
• 1q21.1 deletion syndrome
• 1q21.1 duplication syndrome

Further reading

• Jang KL, Collins MK, Latchman DS (1992). "The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC". Journal of Acquired Immune Deficiency Syndromes. 5 (11): 1142–7. PMID 1403646.
• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Hsieh YJ, Wang Z, Kovelman R, Roeder RG (July 1999). "Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III". Molecular and Cellular Biology. 19 (7): 4944–52. doi:10.1128/mcb.19.7.4944. PMC 84305. PMID 10373544.
• Hsieh YJ, Kundu TK, Wang Z, Kovelman R, Roeder RG (November 1999). "The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity". Molecular and Cellular Biology. 19 (11): 7697–704. doi:10.1128/mcb.19.11.7697. PMC 84812. PMID 10523658.
• Kuwana M, Kimura K, Kawakami Y (October 2002). "Identification of an immunodominant epitope on RNA polymerase III recognized by systemic sclerosis sera: application to enzyme-linked immunosorbent assay". Arthritis and Rheumatism. 46 (10): 2742–7. doi:10.1002/art.10521. PMID 12384934.