PECR

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Peroxisomal trans-2-enoyl-CoA reductase is an enzyme that in humans is encoded by the PECR gene.

PECR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1YXM
Identifiers
Aliases	PECR, DCRRP, HPDHASE, HSA250303, PVIARL, SDR29C1, TERP, peroxisomal trans-2-enoyl-CoA reductase
External IDs	OMIM: 605843; MGI: 2148199; HomoloGene: 69255; GeneCards: PECR; OMA:PECR - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q35 Start 215,996,329 bp End 216,082,955 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1 C3|1 36.46 cM Start 72,298,326 bp End 72,323,473 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in renal medulla buccal mucosa cell nipple ventral tegmental area synovial joint cardia trigeminal ganglion subthalamic nucleus external globus pallidus spinal ganglia Top expressed in right kidney human kidney left lobe of liver zygote primary oocyte proximal tubule secondary oocyte lacrimal gland parotid gland epithelium of small intestine More reference expression data BioGPS More reference expression data
Gene ontology Molecular function oxidoreductase activity signaling receptor binding 2,4-dienoyl-CoA reductase (NADPH) activity trans-2-enoyl-CoA reductase (NADPH) activity Cellular component peroxisome mitochondrion peroxisomal membrane cytosol Biological process phytol metabolic process fatty acid biosynthetic process fatty acid metabolic process lipid metabolism fatty acid alpha-oxidation protein targeting to peroxisome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55825 111175 Ensembl ENSG00000115425 ENSMUSG00000026189 UniProt Q9BY49 Q99MZ7 RefSeq (mRNA) NM_018441 NM_023523 NM_001356516 RefSeq (protein) NP_060911 NP_076012 NP_001343445 Location (UCSC) Chr 2: 216 – 216.08 Mb Chr 1: 72.3 – 72.32 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Gay F, Anglade I, Gong Z, et al. (2001). "The LIM/homeodomain protein islet-1 modulates estrogen receptor functions". Mol. Endocrinol. 14 (10): 1627–48. doi:10.1210/mend.14.10.0538. PMID 11043578.
• Jia L, Young MF, Powell J, et al. (2002). "Gene expression profile of human bone marrow stromal cells: high-throughput expressed sequence tag sequencing analysis". Genomics. 79 (1): 7–17. doi:10.1006/geno.2001.6683. PMID 11827452.
• Braastad CD, Leguia M, Hendrickson EA (2002). "Ku86 autoantigen related protein-1 transcription initiates from a CpG island and is induced by p53 through a nearby p53 response element". Nucleic Acids Res. 30 (8): 1713–24. doi:10.1093/nar/30.8.1713. PMC 113227. PMID 11937624.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
• Gloerich J, Ruiter JP, van den Brink DM, et al. (2006). "Peroxisomal trans-2-enoyl-CoA reductase is involved in phytol degradation". FEBS Lett. 580 (8): 2092–6. doi:10.1016/j.febslet.2006.03.011. PMID 16546181. S2CID 34148550.