Olga Vladimirovna Boudker (Russian: Ольга Владимировна Будкер) is a Russian born physicist who is a professor of physiology and biophysics at the Weill Cornell Medicine. She looks to understand the mechanisms of membrane transporters in cellular function. She was elected a fellow of the National Academy of Sciences in 2022.
Olga Boudker | |
|---|---|
| Alma mater | Novosibirsk State University Johns Hopkins University Weizmann Institute of Science |
| Scientific career | |
| Institutions | Weill Cornell Medicine Massachusetts Institute of Technology |
| Thesis | Conformational stability of large oligometric proteins (1999) |
Early life and education
editBoudker was born in Russia and is a third generation scientist.[1] She was an undergraduate student at the Novosibirsk State University.[2] She moved to the Weizmann Institute of Science for graduate studies, working on the biochemistry of sphingolipids.[2] She joined Johns Hopkins University for her doctoral research, investigating the stability of oligomeric proteins.[3] Boudker then joined Massachusetts Institute of Technology and Columbia University as a postdoctoral fellow.[citation needed] During her postdoctoral research she became interested in the mechanisms of membrane transporters.
Research and career
editBoudker started her lab at the Weill Cornell Medical College in 2005.[4] Her research considers the molecular mechanisms that underpin cellular function, with a focus on transporter proteins.[5][6] She has developed a suite of structural probes to better understand these processes, including cryogenic electron microscopy. In 2015, she was named a Howard Hughes Medical Institute investigator.[7]
In 2021, Boudker was appointed the Acting Chair of Biophysics.[8] In 2022, she was elected Fellow of the National Academy of Sciences.[9]
Selected publications
edit- Olga Boudker; Renae M Ryan; Dinesh Yernool; Keiko Shimamoto; Eric Gouaux (25 January 2007). "Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter". Nature. 445 (7126): 387–93. doi:10.1038/NATURE05455. ISSN 1476-4687. PMID 17230192. Wikidata Q27643578.
- David Drew; Olga Boudker (21 March 2016). "Shared Molecular Mechanisms of Membrane Transporters". Annual Review of Biochemistry. 85: 543–572. doi:10.1146/ANNUREV-BIOCHEM-060815-014520. ISSN 0066-4154. PMID 27023848. Wikidata Q38792631.
- Dinesh Yernool; Olga Boudker; Yan Jin; Eric Gouaux (1 October 2004). "Structure of a glutamate transporter homologue from Pyrococcus horikoshii". Nature. 431 (7010): 811–818. doi:10.1038/NATURE03018. ISSN 1476-4687. PMID 15483603. Wikidata Q30032687.
References
edit- ^ "Dr. Olga Boudker's Work with Glutamate Pumps Earns her Membership in an Elite Cadre of Investigators". Weill Cornell Medicine. January 19, 2016. Retrieved May 2, 2023.
- ^ a b "Olga Boudker, PhD". Tri-Institutional PhD Program in Chemical Biology. Retrieved 2023-04-29.
- ^ "Conformational stability of large oligometric proteins | WorldCat.org". www.worldcat.org. Retrieved 2023-04-29.
- ^ "People". Boudker Lab. Retrieved 2023-04-29.
- ^ "Olga Boudker". HHMI. Retrieved 2023-04-29.
- ^ Ciftci, Didar; Martens, Chloe; Ghani, Vishnu G.; Blanchard, Scott C.; Politis, Argyris; Huysmans, Gerard H. M.; Boudker, Olga (2021-12-07). "Linking function to global and local dynamics in an elevator-type transporter". Proceedings of the National Academy of Sciences. 118 (49): e2025520118. doi:10.1073/pnas.2025520118. ISSN 0027-8424. PMC 8670510. PMID 34873050.
- ^ "HHMI Selects 26 of the Nation's Top Biomedical Scientists". HHMI. Retrieved 2023-04-29.
- ^ "Boudker, Olga". vivo.weill.cornell.edu. Retrieved 2023-04-29.
- ^ "Dr. Olga Boudker Elected to the National Academy of Sciences". WCM Newsroom. Retrieved 2023-04-29.