OTUD1

OTU deubiquitinase 1 is a protein that in humans is encoded by the OTUD1 gene.

OTUD1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4BOP
Identifiers
Aliases	OTUD1, DUBA7, OTDC1, OTU deubiquitinase 1
External IDs	OMIM: 612022; MGI: 1918448; HomoloGene: 45953; GeneCards: OTUD1; OMA:OTUD1 - orthologs
Gene location (Human) Chr. Chromosome 10 (human) Band 10p12.2 Start 23,439,075 bp End 23,442,377 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 A3 Start 19,662,563 bp End 19,665,394 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell Skeletal muscle tissue of rectus abdominis myocardium of left ventricle cardiac muscle tissue of right atrium skin of arm tibialis anterior muscle amniotic fluid muscle of thigh skin of thigh vena cava Top expressed in ascending aorta aortic valve soleus muscle tibialis anterior muscle quadriceps femoris muscle thoracic diaphragm muscle of thigh secondary oocyte digastric muscle ankle More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 220213 71198 Ensembl ENSG00000165312 ENSMUSG00000043415 UniProt Q5VV17 Q9CUB6 RefSeq (mRNA) NM_001145373 NM_027715 RefSeq (protein) NP_001138845 NP_081991 Location (UCSC) Chr 10: 23.44 – 23.44 Mb Chr 2: 19.66 – 19.67 Mb PubMed search
Wikidata
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Function

Deubiquitinating enzymes (DUBs; see MIM 603478) are proteases that specifically cleave ubiquitin (MIM 191339) linkages, negating the action of ubiquitin ligases. DUBA7 belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human OTU domain-containing protein 1

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.