OR1A2

Olfactory receptor 1A2 is a protein that in humans is encoded by the OR1A2 gene.

OR1A2
Identifiers
Aliases	OR1A2, OR17-6, olfactory receptor family 1 subfamily A member 2
External IDs	OMIM: 618047; MGI: 3030237; GeneCards: OR1A2; OMA:OR1A2 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17p13.3 Start 3,197,519 bp End 3,198,448 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 B5 Start 74,077,075 bp End 74,089,438 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane Biological process positive regulation of cytokinesis sensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26189 404316 Ensembl ENSG00000172150 ENSMUSG00000070378 UniProt Q9Y585 Q7TRX2 RefSeq (mRNA) NM_012352 NM_207622 RefSeq (protein) NP_036484 NP_997505 Location (UCSC) Chr 17: 3.2 – 3.2 Mb Chr 11: 74.08 – 74.09 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

Ligands

The known ligands of OR1A2 are near-identical to those of OR1A1. Examples of known ligands, most of which have citrus or fruity smells:

• (S)-(−)-citronellal
• Helional
• Heptanal
• Octanal
• Nonanal (weaker than heptanal/octanal)
• Hydroxycitronellal
• Citral
• (S)-(−)-Citronellol (in contrast to OR1A1 only this enantiomer is effective; weaker than citronellal)

See also

• Olfactory receptor

References

• This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Further reading

• Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID 12213199.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links

• OR1A2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)