Ndubuisi is a given name. Notable people with the given name include:
- Haggai Ndubuisi (born 2000), Nigerian gridiron football player
- Ndubuisi Egbo (born 1973), Nigerian football manager and former footballer
- Ndubuisi Ekekwe (born 1975), Nigerian professor, inventor, engineer, author and entrepreneur
- Ndubuisi Eze (born 1984), Nigerian footballer
- Ndubuisi Kanu (born 1943), Nigerian military governor
- Ndubuisi Okosieme (born 1966), Nigerian footballer