NRN1

NRN1
Identifiers
Aliases	NRN1, NRN, dJ380B8.2, neuritin 1
External IDs	OMIM: 607409; MGI: 1915654; HomoloGene: 9577; GeneCards: NRN1; OMA:NRN1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	6,007,605 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	36,919,105 bp
RNA expression pattern
	Top expressed in
	cerebellar cortex; ; cerebellar hemisphere; ; orbitofrontal cortex; ; dorsolateral prefrontal cortex; ; right frontal lobe; ; right hemisphere of cerebellum; ; ganglionic eminence; ; superior frontal gyrus; ; prefrontal cortex; ; cerebellar vermis;
	Top expressed in
	habenula; ; piriform cortex; ; cumulus cell; ; visual cortex; ; primary motor cortex; ; primary visual cortex; ; dentate gyrus; ; prefrontal cortex; ; hippocampus proper; ; left lobe of liver;
	More reference expression data
	n/a
Orthologs
	51299
	68404
	ENSG00000124785
	ENSMUSG00000039114
	Q9NPD7
	Q8CFV4
	NM_001278710; NM_001278711; NM_016588
	NM_153529; NM_001374754
	NP_001265639; NP_001265640; NP_057672
	NP_705757; NP_001361683
	Wikidata
View/Edit Human	View/Edit Mouse

Neuritin 1 is a protein that in humans is encoded by the NRN1 gene. ^[5]

Function

This gene encodes a member of the neuritin family, and is expressed in postmitotic-differentiating neurons of the developmental nervous system and neuronal structures associated with plasticity in the adult. The expression of this gene can be induced by neural activity and neurotrophins. The encoded protein contains a consensus cleavage signal found in glycosylphoshatidylinositol (GPI)-anchored proteins. The encoded protein promotes neurite outgrowth and arborization, suggesting its role in promoting neuritogenesis. Overexpression of the encoded protein may be associated with astrocytoma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000124785 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039114 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Neuritin 1". Retrieved 2017-12-15.

Le Jan S, Le Meur N, Cazes A, Philippe J, Le Cunff M, Léger J, Corvol P, Germain S (2006). "Characterization of the expression of the hypoxia-induced genes neuritin, TXNIP and IGFBP3 in cancer". FEBS Lett. 580 (14): 3395–400. CiteSeerX 10.1.1.326.1157. doi:10.1016/j.febslet.2006.05.011. PMID 16723126. S2CID 10052776.
Fujino T, Wu Z, Lin WC, Phillips MA, Nedivi E (2008). "cpg15 and cpg15-2 constitute a family of activity-regulated ligands expressed differentially in the nervous system to promote neurite growth and neuronal survival". J. Comp. Neurol. 507 (5): 1831–45. doi:10.1002/cne.21649. PMC 2828060. PMID 18265009.
Chandler D, Dragović M, Cooper M, Badcock JC, Mullin BH, Faulkner D, Wilson SG, Hallmayer J, Howell S, Rock D, Palmer LJ, Kalaydjieva L, Jablensky A (2010). "Impact of Neuritin 1 (NRN1) polymorphisms on fluid intelligence in schizophrenia". Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (2): 428–437. doi:10.1002/ajmg.b.30996. PMID 19569075. S2CID 24983584.
Zhang L, Zhao Y, Wang CG, Fei Z, Wang Y, Li L, Li L, Zhen HN (2011). "Neuritin expression and its relation with proliferation, apoptosis, and angiogenesis in human astrocytoma". Med. Oncol. 28 (3): 907–12. doi:10.1007/s12032-010-9537-9. PMID 20405246. S2CID 25680435.
Akten B, Kye MJ, Hao le T, Wertz MH, Singh S, Nie D, Huang J, Merianda TT, Twiss JL, Beattie CE, Steen JA, Sahin M (2011). "Interaction of survival of motor neuron (SMN) and HuD proteins with mRNA cpg15 rescues motor neuron axonal deficits". Proc. Natl. Acad. Sci. U.S.A. 108 (25): 10337–42. Bibcode:2011PNAS..10810337A. doi:10.1073/pnas.1104928108. PMC 3121858. PMID 21652774.
Gao R, Wang L, Sun J, Nie K, Jian H, Gao L, Liao X, Zhang H, Huang J, Gan S (2014). "MiR-204 promotes apoptosis in oxidative stress-induced rat Schwann cells by suppressing neuritin expression". FEBS Lett. 588 (17): 3225–32. doi:10.1016/j.febslet.2014.07.004. PMID 25036738. S2CID 24215014.
Choi Y, Lee K, Ryu J, Kim HG, Jeong AY, Woo RS, Lee JH, Hyun JW, Hahn S, Kim JH, Kim HS (2014). "Neuritin attenuates cognitive function impairments in tg2576 mouse model of Alzheimer's disease". PLOS ONE. 9 (8): e104121. Bibcode:2014PLoSO...9j4121C. doi:10.1371/journal.pone.0104121. PMC 4125179. PMID 25101829.
Wang X, Liu C, Xu F, Cui L, Tan S, Chen R, Yang L, Huang J (2015). "Effects of neuritin on the migration, senescence and proliferation of human bone marrow mesenchymal stem cells". Cell. Mol. Biol. Lett. 20 (3): 466–74. doi:10.1515/cmble-2015-0026. PMID 26208391.
Fatjó-Vilas M, Prats C, Pomarol-Clotet E, Lázaro L, Moreno C, González-Ortega I, Lera-Miguel S, Miret S, Muñoz MJ, Ibáñez I, Campanera S, Giralt-López M, Cuesta MJ, Peralta V, Ortet G, Parellada M, González-Pinto A, McKenna PJ, Fañanás L (2016). "Involvement of NRN1 gene in schizophrenia-spectrum and bipolar disorders and its impact on age at onset and cognitive functioning" (PDF). World J. Biol. Psychiatry. 17 (2): 129–39. doi:10.3109/15622975.2015.1093658. hdl:2445/69596. PMID 26700405. S2CID 39722608.

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000124785 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000039114 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Neuritin 1". Retrieved 2017-12-15.

[5]

[1]

[2]

[3]

[4]

NRN1

Function

References

Further reading